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Open Access
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| Open AccessAxonemal structures reveal mechanoregulatory and disease mechanisms
Detailed atomic models of axonemes from algal flagella and human respiratory cilia, which are hair-like protrusions from cells that enable motility and clear mucus from human airways, could provide insights into how they function.
- Travis Walton
- , Miao Gui
- & Alan Brown
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Article
| Open AccessOocytes maintain ROS-free mitochondrial metabolism by suppressing complex I
Oocytes prevent the production of reactive oxygen species by remodelling the mitochondrial electron transport chain through elimination of complex I, a strategy that enables their long-term viability.
- Aida Rodríguez-Nuevo
- , Ariadna Torres-Sanchez
- & Elvan Böke
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Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma
Analyses of samples from 728 women with uterine leiomyomas (uterine fibroids), and public data, show that somatic and germline mutations in the SRCAP histone-loading complex genes are associated with the condition.
- Davide G. Berta
- , Heli Kuisma
- & Lauri A. Aaltonen
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Perspective
| Open AccessThe Integrative Human Microbiome Project
Over ten years, the Human Microbiome Project has provided resources for studying the microbiome and its relationship to disease; this Perspective summarizes the key achievements and findings of the project and its relationship to the broader field.
- Lita M. Proctor
- , Heather H. Creasy
- & Curtis Huttenhower
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First road map of human sex-cell development
Study marks a step towards stem-cell treatment of infertility.
- Becky Summers
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Research Highlights |
Cancer-drug infertility reversed
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News & Views |
Stem cells bear eggs
Researchers have coaxed cultured embryonic stem cells to develop into eggs that then give rise to normal offspring. The discovery should help to decode the molecular basis of gamete formation and might lead to treatments for infertility.
- Sihem Cheloufi
- & Konrad Hochedlinger
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Research Highlights |
Molecular clues to infertility
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Letter |
In vitro production of functional sperm in cultured neonatal mouse testes
Reproducing the complex process of spermatogenesis in vitro might lead to the development of new diagnostic and therapeutic techniques for male infertility. This study establishes in vitro organ culture conditions that can support complete spermatogenesis in mice. The in-vitro-derived spermatids and sperm produced healthy and fertile mice, and testis tissue fragments used as a starting material for in vitro spermatogenesis could be cryopreserved for months and then resumed full spermatogenesis in vitro.
- Takuya Sato
- , Kumiko Katagiri
- & Takehiko Ogawa
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Female hormone could be key to male contraceptive
Progesterone-sensing molecule that guides sperm to egg offers fertility solution.
- Ewen Callaway
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Of femurs and fertility
Mouse studies suggest bone hormone affects male fertility.
- Tiffany O'Callaghan
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MicroRNAs mediate an early birth
Researchers uncover the molecular process that triggers contractions during labour.
- Joseph Milton