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| Open AccessComputational investigation of IP3 diffusion
- Roberto Ornelas-Guevara
- , Diana Gil
- & Geneviève Dupont
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| Open AccessThe spatial distribution of GPCR and Gβγ activity across a cell dictates PIP3 dynamics
- Dhanushan Wijayaratna
- , Kasun Ratnayake
- & Ajith Karunarathne
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Article
| Open AccessButyrate limits human natural killer cell effector function
- Vanessa Zaiatz-Bittencourt
- , Fiona Jones
- & Elizabeth J. Ryan
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| Open AccessModulation of transcription factor dynamics allows versatile information transmission
- Alan Givré
- , Alejandro Colman-Lerner
- & Silvina Ponce Dawson
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Article
| Open AccessHippo pathway inhibition promotes metabolic adaptability and antioxidant response in myoblasts
- Qi Liu
- , Su Pan
- & Richard A. F. Dixon
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| Open AccessMacromolecular crowding regulates matrix composition and gene expression in human gingival fibroblast cultures
- Rajesvaran Ramalingam
- , Guoqiao Jiang
- & Lari Häkkinen
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| Open AccessSimultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration
- Chulo Park
- , Jin-Woo Lee
- & Won-Ki Huh
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| Open Access3D osteogenic differentiation of human iPSCs reveals the role of TGFβ signal in the transition from progenitors to osteoblasts and osteoblasts to osteocytes
- Shunsuke Kawai
- , Junko Sunaga
- & Junya Toguchida
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Article
| Open AccessTranscriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival and propagation of multiple human colorectal cancer cell lines
- Janna Fröhlich
- , Katja Rose
- & Andreas Hecht
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Article
| Open AccessFibroblast growth factor-2 bound to specific dermal fibroblast-derived extracellular vesicles is protected from degradation
- Isabelle Petit
- , Ayelet Levy
- & Olivier Ferrigno
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| Open AccessThe release of osteoclast-stimulating factors on supraphysiological loading by osteoprogenitors coincides with expression of genes associated with inflammation and cytoskeletal arrangement
- Cornelia Bratengeier
- , Astrid D. Bakker
- & Anna Fahlgren
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| Open AccessSTAT3 suppression and β-cell ablation enhance α-to-β reprogramming mediated by Pdx1
- Yuka Wakabayashi
- , Takeshi Miyatsuka
- & Hirotaka Watada
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Article
| Open AccessNrf2 and Parkin-Hsc70 regulate the expression and protein stability of p62/SQSTM1 under hypoxia
- Ferbian Milas Siswanto
- , Yumi Mitsuoka
- & Susumu Imaoka
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Article
| Open AccessThe mitochondrial Ca2+ uniporter channel synergizes with fluid shear stress to induce mitochondrial Ca2+ oscillations
- Akshar Patel
- , Matthew Simkulet
- & B. Rita Alevriadou
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Article
| Open AccessRac1 deficiency impairs postnatal development of the renal papilla
- Nobuhiro Ayuzawa
- , Mitsuhiro Nishimoto
- & Toshiro Fujita
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Article
| Open AccessEpithelial membrane protein 2 (EMP2) regulates hypoxia-induced angiogenesis in the adult retinal pigment epithelial cell lines
- Michel Sun
- , Nina Cherian
- & Madhuri Wadehra
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Article
| Open AccessCdGAP maintains podocyte function and modulates focal adhesions in a Src kinase-dependent manner
- Jun Matsuda
- , Dina Greenberg
- & Tomoko Takano
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Article
| Open AccessButyrate reduces cellular magnesium absorption independently of metabolic regulation in Caco-2 human colon cells
- Lisanne M. M. Gommers
- , Pieter A. Leermakers
- & Joost G. J. Hoenderop
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Article
| Open AccessProtection of insect neurons by erythropoietin/CRLF3-mediated regulation of pro-apoptotic acetylcholinesterase
- Debbra Y. Knorr
- , Kristin Schneider
- & Ralf Heinrich
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Article
| Open AccessPlatelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts
- Hoa T. Le
- , Kalyan Golla
- & Hugh Kim
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Article
| Open AccessRelating individual cell division events to single-cell ERK and Akt activity time courses
- Alan D. Stern
- , Gregory R. Smith
- & Marc R. Birtwistle
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Article
| Open AccessThe autophagy inducer SMER28 attenuates microtubule dynamics mediating neuroprotection
- Marco Kirchenwitz
- , Stephanie Stahnke
- & Theresia E. B. Stradal
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Article
| Open AccessVitamin D enhances type I IFN signaling in COVID-19 patients
- Shirin Hafezi
- , Fatemeh Saheb Sharif-Askari
- & Rabih Halwani
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Article
| Open AccessGeneration and characterization of a Müller-glial-cell-specific Il6ra knockout mouse to delineate the effects of IL-6 trans-signaling in the retina
- Rebekah Robinson
- , Joshua Glass
- & Shruti Sharma
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| Open AccessMultiomics analysis reveals that hepatocyte nuclear factor 1β regulates axon guidance genes in the developing mouse kidney
- Annie Shao
- , Micah D. Gearhart
- & Peter Igarashi
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Article
| Open AccessThe LRP1/CD91 ligands, tissue-type plasminogen activator, α2-macroglobulin, and soluble cellular prion protein have distinct co-receptor requirements for activation of cell-signaling
- Elisabetta Mantuano
- , Pardis Azmoon
- & Steven L. Gonias
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| Open AccessIdentification of in vivo roles of ErbB4-JMa and its direct nuclear signaling using a novel isoform-specific knock out mouse
- Robert Doherty
- , Brenna L. MacLeod
- & Gabriel Corfas
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Article
| Open AccessThe effect of short-term refrigeration on platelet responsiveness
- Anna Kobsar
- , Karina Koehnlechner
- & Juergen Koessler
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Article
| Open AccessCDK4/6 initiates Rb inactivation and CDK2 activity coordinates cell-cycle commitment and G1/S transition
- Sungsoo Kim
- , Alessandra Leong
- & Hee Won Yang
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Article
| Open AccessSarco/endoplasmic reticulum calcium ATPase activity is unchanged despite increased myofilament calcium sensitivity in Zucker type 2 diabetic fatty rat heart
- Yann Huey Ng
- , Regis R. Lamberts
- & James C. Baldi
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Article
| Open AccessExtracranial arteriovenous malformations demonstrate dysregulated TGF-β/BMP signaling and increased circulating TGF-β1
- Ting Wei
- , Gresham T. Richter
- & Graham M. Strub
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Article
| Open AccessProtein interaction, cytotoxic, transcriptomic and proteomic responses to structurally distinct EPAC1 activators in HUVECs
- Jolanta Wiejak
- , Urszula Luchowska-Stańska
- & Stephen J. Yarwood
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| Open AccessSex-based differences in conjunctival goblet cell responses to pro-inflammatory and pro-resolving mediators
- Menglu Yang
- , Haakon K. Fjærvoll
- & Darlene A. Dartt
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| Open AccessLive imaging of delamination in Drosophila shows epithelial cell motility and invasiveness are independently regulated
- Mikiko Inaki
- , Smitha Vishnu
- & Kenji Matsuno
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Article
| Open AccessGingival epithelial cell-derived microvesicles activate mineralization in gingival fibroblasts
- Shuichiro Kobayashi
- , Jiarui Bi
- & Hannu Larjava
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Article
| Open AccessUterine extracellular vesicles as multi-signal messengers during maternal recognition of pregnancy in the mare
- Alba Rudolf Vegas
- , Meriem Hamdi
- & Carmen Almiñana
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Article
| Open AccessA new triazolothiadiazine derivative inhibits stemness and induces cell death in HCC by oxidative stress dependent JNK pathway activation
- Deniz Cansen Kahraman
- , Ebru Bilget Guven
- & Rengul Cetin Atalay
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Article
| Open AccessLack of adducin impairs the stability of endothelial adherens and tight junctions and may be required for cAMP-Rac1-mediated endothelial barrier stabilization
- Sina Moztarzadeh
- , Mariya Y. Radeva
- & Alexander García-Ponce
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Article
| Open AccessXanthohumol exerts anti-inflammatory effects in an in vitro model of mechanically stimulated cementoblasts
- Christian Niederau
- , Shruti Bhargava
- & Michael Wolf
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| Open AccessSmall molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function
- Gaochao Tian
- , Steven R. Katchur
- & William L. Rumsey
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| Open AccessInsulin sensitivity is associated with the observed variation of de novo lipid synthesis and body composition in finishing pigs
- Hector Hernando Salgado
- , Candido Pomar
- & Aline Remus
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| Open AccessRSPO3 is a novel contraction-inducible factor identified in an “in vitro exercise model” using primary human myotubes
- Tadahisa Takahashi
- , Yuqing Li
- & Makoto Kanzaki
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| Open AccessDifferential gene expression in iPSC-derived human intestinal epithelial cell layers following exposure to two concentrations of butyrate, propionate and acetate
- Menno Grouls
- , Aafke W. F. Janssen
- & Meike van der Zande
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| Open AccessCharacterization of presence and activity of microRNAs in the rumen of cattle hints at possible host-microbiota cross-talk mechanism
- Sara Ricci
- , Renée M. Petri
- & Susanne Kreuzer-Redmer
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| Open AccessTGFβ-induced changes in membrane curvature influence Ras oncoprotein membrane localization
- Alexandros Damalas
- , Ivana Vonkova
- & Dimitrios Stamou
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| Open AccessThe E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis
- Natalie Vaughan
- , Nico Scholz
- & Julien D. F. Licchesi
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Article
| Open AccessLITOS: a versatile LED illumination tool for optogenetic stimulation
- Thomas Christoph Höhener
- , Alex Erich Landolt
- & Olivier Pertz
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| Open AccessR-spondin3 is a myokine that differentiates myoblasts to type I fibres
- Yoshitaka Mita
- , Haonan Zhu
- & Nobuharu L. Fujii
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| Open AccessDJ-1 interacts with the ectopic ATP-synthase in endothelial cells during acute ischemia and reperfusion
- Alex Gallinat
- & Lina Badimon