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| Open AccessTherapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells
- Pratim Chowdhury
- , Dimuthu Perera
- & Ruhee Dere
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| Open AccessActivation of PAR2 by tissue factor induces the release of the PTEN from MAGI proteins and regulates PTEN and Akt activities
- Mohammad A. Mohammad
- , John Greenman
- & Camille Ettelaie
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| Open AccessFrom extraocular photoreception to pigment movement regulation: a new control mechanism of the lanternshark luminescence
- Laurent Duchatelet
- , Tomohiro Sugihara
- & Jérôme Mallefet
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| Open AccessConverging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage
- Braulio Henrique Freire Lima
- , Pedro Elias Marques
- & Mauro Martins Teixeira
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| Open AccessAβ modulates actin cytoskeleton via SHIP2-mediated phosphoinositide metabolism
- Hae Nim Lee
- , Kyoung Mi Sim
- & Jihye Seong
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| Open AccessThe Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif
- Mo Chen
- , Suyong Choi
- & Richard A. Anderson
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| Open AccessCritical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function
- Samantha F. Moore
- , Nina R. Smith
- & Ingeborg Hers
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| Open AccessIdentification of the Binding Sites on Rab5 and p110beta Phosphatidylinositol 3-kinase
- Dielle E. Whitecross
- & Deborah H. Anderson
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| Open AccessPharmacological Inhibition of PTEN Aggravates Acute Kidney Injury
- Jun Zhou
- , Li Jia
- & Yanlin Wang
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| Open AccessRegulation of HGF-induced hepatocyte proliferation by the small GTPase Arf6 through the PIP2-producing enzyme PIP5K1A
- Meng-Tsz Tsai
- , Naohiro Katagiri
- & Yuji Funakoshi
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| Open AccessTargeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis
- R. Reilly
- , M. S. Mroz
- & J. A. Coppinger
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| Open AccessSuppression of cell migration by phospholipase C-related catalytically inactive protein-dependent modulation of PI3K signalling
- Satoshi Asano
- , Yuri Taniguchi
- & Takashi Kanematsu
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| Open AccessEndotoxin tolerance in mast cells, its consequences for IgE-mediated signalling, and the effects of BCL3 deficiency
- Magdalena Poplutz
- , Maryna Levikova
- & Michael Huber
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| Open AccessCombination of RAD001 (everolimus) and docetaxel reduces prostate and breast cancer cell VEGF production and tumour vascularisation independently of sphingosine-kinase-1
- Heba Alshaker
- , Qi Wang
- & Dmitri Pchejetski
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| Open AccessInterplay of DNA methyltransferase 1 and EZH2 through inactivation of Stat3 contributes to β-elemene-inhibited growth of nasopharyngeal carcinoma cells
- JingJing Wu
- , Qing Tang
- & Swei Sunny Hann
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| Open AccessMiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway
- Mao Luo
- , Xiaoyong Tan
- & Qin Wan
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| Open AccessA molecular determinant of phosphoinositide affinity in mammalian TRPV channels
- Phanindra Velisetty
- , Istvan Borbiro
- & Tibor Rohacs
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| Open AccessIdentification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence
- Cecilia Li
- , Sophie Lev
- & Julianne T. Djordjevic
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| Open AccessRNF135, RING finger protein, promotes the proliferation of human glioblastoma cells in vivo and in vitro via the ERK pathway
- Yongjian Liu
- , Feng Wang
- & Yinghui Xu
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| Open AccessA Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2
- Susanne B. Breitkopf
- , Xuemei Yang
- & John M. Asara
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| Open AccessSPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination
- Nathan R. Wilson
- , Adam J. Olm-Shipman
- & Irfan Saadi
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| Open AccessNitro-oleic acid downregulates lipoprotein-associated phospholipase A2 expression via the p42/p44 MAPK and NFκB pathways
- Gangqi Wang
- , Yuan Ji
- & Xiaochun Tang
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| Open AccessCSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner
- Akihiro Yoshida
- , Noriko Yoneda-Kato
- & Jun-ya Kato