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| Open AccessSpatial and temporal dynamics of West Nile virus between Africa and Europe
West Nile virus is an animal pathogen that has spread rapidly in Europe in recent years, causing several human deaths. This study investigates the spatial and temporal dynamics of the virus circulation between Africa (its place of origin) and Europe.
- Giulia Mencattelli
- , Marie Henriette Dior Ndione
- & Giovanni Savini
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| Open AccessBlockade of interferon signaling decreases gut barrier integrity and promotes severe West Nile virus disease
In this study, Lin and Zhao et al. show that type I IFN autoantibodies promote West Nile virus infection in enterocytes, which correlates with encephalitis disease risk in humans; while in mice, type I IFN signaling defects associate with gastrointestinal tract and blood-brain barrier permeability and disease severity.
- Shih-Ching Lin
- , Fang R. Zhao
- & Michael S. Diamond
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Article
| Open AccessEpidemiological hypothesis testing using a phylogeographic and phylodynamic framework
Classical epidemiological approaches have been limited in their ability to formally test hypotheses. Here, Dellicour et al. illustrate how phylodynamic and phylogeographic analyses can be leveraged for hypothesis testing in molecular epidemiology using West Nile virus in North America as an example.
- Simon Dellicour
- , Sebastian Lequime
- & Philippe Lemey