Vitiligo articles within Nature Communications

Featured

• Article
  27 January 2024 | Open Access

  Sexual dimorphism in melanocyte stem cell behavior reveals combinational therapeutic strategies for cutaneous repigmentation

  Vitiligo is an autoimmune condition that results in skin depigmentation due to melanocyte loss, but the root causes are not well understood. Here they identify sexual dimorphism in melanocyte stem cells behavior arising from distinct skin inflammatory responses, and propose Prostaglandin E2 as a potential therapy for depigmentation conditions.

  • Luye An
  • , Dahihm Kim
  •  & Andrew C. White

• Article
  16 May 2019 | Open Access

  Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo

  Tissue signals that prime autoreactive T cells at the onset of autoimmunity remain enigmatic. Here the authors show NK and ILC1 cells are increased in vitiligo patients, and induce melanocyte apoptosis via CXCR3B, which in turn leads to increased priming of T cell responses in cell culture.

  • Meri K. Tulic
  • , Elisa Cavazza
  •  & Thierry Passeron

• Article
  23 January 2019 | Open Access

  Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression

  GWAS have led to the identification of 49 genetic loci associated with vitiligo. Here, the authors observe a bimodal distribution of age-of-onset and find a novel genetic locus specifically associated with early-onset vitiligo, located in a regulatory element in the MHC class II region.

  • Ying Jin
  • , Genevieve H. L. Roberts
  •  & Richard A. Spritz