Systems virology articles within Nature Communications

Featured

  • Article
    | Open Access

    The diversity and impact of viruses in remote marine environments are less well understood. In this study, the authors analyse an -omics dataset to gain insights into the genomics and potential role of endemic viruses infecting ecologically important microbes inhabiting the ocean cavity beneath the Ross Ice Shelf.

    • Javier Lopez-Simon
    • , Marina Vila-Nistal
    •  & Manuel Martinez-Garcia

  • Article
    | Open Access

    Zika virus (ZIKV) infection suppresses the induction of dendritic cell (DC)-derived immunity, but the underlying mechanistical insights are still lacking. Here the authors show, using in vitro systems profiling of DC transcriptome and epigenome, that ZIKV specifically alters SREBP2-related expression of inflammation- and metabolism-related genes to modulate DC functions.

    • Emilie Branche
    • , Ying-Ting Wang
    •  & Aaron F. Carlin

  • Article
    | Open Access

    Here, Hiatt et al. report the knock-out of over 400 genes in primary CD4+ T cells to assess their functional role in HIV replication, finding 86 initial candidates of which 47 are validated as HIV host factors, including 23 with restrictive activity.

    • Joseph Hiatt
    • , Judd F. Hultquist
    •  & Nevan J. Krogan

  • Article
    | Open Access

    Here, Shaban et al. show that coronaviruses modulate ER stress and the unfolded protein response. The ER stress inducer thapsigargin exerts potent antiviral effects, partially reverses the virus-induced translational shut-down, reprograms the host proteome and suppresses autophagic flux, thereby inhibiting coronavirus replication at multiple levels.

    • Mohammed Samer Shaban
    • , Christin Müller
    •  & Michael Kracht

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