Viral infection

Viral infection is the invasion of the body by a small agent known as a virus. Viruses replicate inside host cells and can produce toxins that cause disease. The immune system helps to destroy viruses, but antiviral immune responses can also cause tissue damage and illness.

Latest Research and Reviews

  • Research | | open

    Zika virus infections can cause devastating congenital birth defects but the underlying interactions with the host immune system are not well understood. Here, the authors examine the immune basis of vaginal protection and susceptibility to Zika viral infection, and identify a hormonal dependent role for interferon-lambda-mediated protection against disease.

    • Elizabeth A. Caine
    • , Suzanne M. Scheaffer
    • , Nitin Arora
    • , Konstantin Zaitsev
    • , Maxim N. Artyomov
    • , Carolyn B. Coyne
    • , Kelle H. Moley
    •  & Michael S. Diamond
  • Research | | open

    Genetic screens are important tools to identify host factors associated with viral infections. Here, Flint et al. perform a genome-wide CRISPR screen using infectious Ebola virus (EBOV) and show that the host transferase GNPTAB is required for EBOV infection and a potential target for antiviral therapies

    • Mike Flint
    • , Payel Chatterjee
    • , David L. Lin
    • , Laura K. McMullan
    • , Punya Shrivastava-Ranjan
    • , Éric Bergeron
    • , Michael K. Lo
    • , Stephen R. Welch
    • , Stuart T. Nichol
    • , Andrew W. Tai
    •  & Christina F. Spiropoulou
  • Research | | open

    Current experimental monoclonal antibodies (mAbs) for Ebola virus (EBOV) post-exposure immunotherapy are ineffective against Sudan (SUDV) or Marburg virus (MARV). Here, authors develop cocktails of mAbs that protect nonhuman primates against EBOV, SUDV, and MARV infection when given four days post infection.

    • Jennifer M. Brannan
    • , Shihua He
    • , Katie A. Howell
    • , Laura I. Prugar
    • , Wenjun Zhu
    • , Hong Vu
    • , Sergey Shulenin
    • , Shweta Kailasan
    • , Henna Raina
    • , Gary Wong
    • , Md Niaz Rahim
    • , Logan Banadyga
    • , Kevin Tierney
    • , Xuelian Zhao
    • , Yuxing Li
    • , Frederick W. Holtsberg
    • , John M. Dye
    • , Xiangguo Qiu
    •  & M. Javad Aman
  • Research | | open

    Viruses rely on host cell metabolism for replication, making these pathways potential therapeutic targets. Here, the authors show that AM580, a retinoid derivative and RAR-α agonist, affects replication of several RNA viruses by interfering with the activity of SREBP.

    • Shuofeng Yuan
    • , Hin Chu
    • , Jasper Fuk-Woo Chan
    • , Zi-Wei Ye
    • , Lei Wen
    • , Bingpeng Yan
    • , Pok-Man Lai
    • , Kah-Meng Tee
    • , Jingjing Huang
    • , Dongdong Chen
    • , Cun Li
    • , Xiaoyu Zhao
    • , Dong Yang
    • , Man Chun Chiu
    • , Cyril Yip
    • , Vincent Kwok-Man Poon
    • , Chris Chung-Sing Chan
    • , Kong-Hung Sze
    • , Jie Zhou
    • , Ivy Hau-Yee Chan
    • , Kin-Hang Kok
    • , Kelvin Kai-Wang To
    • , Richard Yi-Tsun Kao
    • , Johnson Yiu-Nam Lau
    • , Dong-Yan Jin
    • , Stanley Perlman
    •  & Kwok-Yung Yuen
  • Reviews |

    Previously, Zika virus was thought to cause mild infection, and serious complications only recently emerged. Liu, Shi and Qin discuss how the virus has evolved during its recent global spread and consider how these changes might be linked to pathogenesis.

    • Zhong-Yu Liu
    • , Wei-Feng Shi
    •  & Cheng-Feng Qin
  • Research |

    The non-structural protein NSs of the severe fever with thrombocytopenia syndrome virus interacts with ABIN2 and promotes formation and signalling of the TPL2–ABIN2–p105 kinase complex to induce expression of the immune-suppressive cytokine IL-10 and enhance viral pathogenesis.

    • Younho Choi
    • , Su-Jin Park
    • , Yinyan Sun
    • , Ji-Seung Yoo
    • , Raghavendra Sumanth Pudupakam
    • , Suan-Sin Foo
    • , Woo-Jin Shin
    • , Sally B. Chen
    • , Philip N. Tsichlis
    • , Won-Ja Lee
    • , Jong-Soo Lee
    • , Wenhui Li
    • , Benjamin Brennan
    • , Young-Ki Choi
    •  & Jae U. Jung

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