The implementation of PCR tests of pooled saliva samples for universal screening of congenital cytomegalovirus infection was assessed in 15,805 neonates over 13 months. This extensive analysis revealed the high feasibility and empirical efficiency of the pooled testing approach, which had a clinically insignificant loss of sensitivity.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Rawlinson, W. D. et al. Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy. Lancet Infect. Dis. 17, e177–e188 (2017). A review article on consensus recommendations for the prevention, diagnosis and therapy of cCMV infection.
Pinninti, S. & Boppana, S. Congenital cytomegalovirus infection diagnostics and management. Curr. Opin. Infect. Dis. 35, 436–441 (2022). A review article on developments in the diagnosis and management of children with cCMV.
Pesch, M. H. & Schleiss, M. R. Emerging concepts in congenital cytomegalovirus. Pediatrics. 150, e2021055896 (2022). A review article on the epidemiology, long-term sequelae, screening approaches and areas for future investigation of cCMV.
Fowler, K. B. et al. A targeted approach for congenital cytomegalovirus screening within newborn hearing screening. Pediatrics 139, e20162128 (2017). This paper reports that 43% of infants with (or at risk for late-onset) CMV-related hearing loss were not identified by targeted cCMV screening.
Barak, N. et al. Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT–PCR tests. Sci. Transl. Med. 13, eabf2823 (2021). This paper reports on our implementation of a sample-pooling pipeline for the efficient detection of SARS-CoV-2.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Merav, L. et al. Implementation of pooled saliva tests for universal screening of cCMV infection. Nat. Med. https://doi.org/10.1038/s41591-024-02873-3 (2024).
Rights and permissions
About this article
Cite this article
Testing pooled samples enables universal screening of congenital cytomegalovirus infection. Nat Med 30, 952–953 (2024). https://doi.org/10.1038/s41591-024-02901-2
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41591-024-02901-2
