Vasculitis syndromes articles within Nature Communications

Featured

• Article
  11 October 2023 | Open Access

  Single-cell multi-omics analysis identifies two distinct phenotypes of newly-onset microscopic polyangiitis

  Autoimmune vasculitis can be heterogeneous in terms of immune cell involvement. Here the authors use a single cell transcriptomics approach to characterise a group of microscopic polyangiitis patients that could be split into two groups typified by monocyte or Interferon associated gene expression.

  • Masayuki Nishide
  • , Kei Nishimura
  •  & Atsushi Kumanogoh

• Article
  29 July 2019 | Open Access

  A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

  Autoreactivity to myeloperoxidase (MPO) causes autoimmune vasculitis and severe glomerulonephritis. Here, Ooi et al. show that a Staphylococcus aureus plasmid encodes a peptide that is homologous to an immunodominant MPO epitope and induces anti-MPO autoimmunity and glomerulonephritis in mice.

  • Joshua D. Ooi
  • , Jhih-Hang Jiang
  •  & A. Richard Kitching