News & Views |
Featured
-
-
Article
| Open AccessA TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2
A nanoparticle-based adjuvant incorporating a Toll-like receptor 7 agonist elicits cross-reactive antibodies for both dominant and subdominant epitopes and enhances immune responses against multiple variants of influenza and SARS-CoV-2.
- Qian Yin
- , Wei Luo
- & Mark M. Davis
-
-
Editorial |
Materials at the heart of the COVID-19 pandemic
Materials scientists have played a key role in the global response to the COVID-19 pandemic from the development of vaccines and diagnostic tools to the rapid prototyping of ventilators.
-
Editorial |
COVID-19 therapies and vaccine landscape
Within a few weeks of the novel coronavirus genome sequence being published, numerous therapies and vaccines have entered clinical trials with a few showing great promise in alleviating symptoms and accelerating recovery.
-
Comment |
Next-generation vaccine platforms for COVID-19
Consensus among experts is that only an effective COVID-19 vaccine will end the pandemic. This Comment focuses on how this pandemic has accelerated the development of vaccine platforms distinct from classical vaccines; these novel platforms may also increase the response time when new viruses emerge in the future.
- Debby van Riel
- & Emmie de Wit
-
News & Views |
Next-generation malarial vaccines
A vaccine platform developed from a synthetic polymeric glyco-adjuvant and reversibly conjugated to an antigen was shown to target dendritic cells leading to cellular and humoral immune response against malaria.
- Yvette van Kooyk
-
Article |
Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity
A vaccine platform has been developed from a polymeric glyco-adjuvant conjugated to an antigen, and is now shown to target dendritic cells via mannose-binding receptors and generate potent cellular and humoral immune response against malaria.
- D. Scott Wilson
- , Sachiko Hirosue
- & Jeffrey A. Hubbell
-
News & Views |
Smart delivery of vaccines
A strategy to enhance antigen immunogenicity was developed by adsorption of polyethyleneimine on a mesoporous silica microrod vaccine for the presentation of tumour viruses and neoantigens, demonstrating their ability to drive anti-tumour immunity.
- Cornelis J. M. Melief
-
News & Views |
Softness makes it better
An effective adjuvant for the induction of humoural and cellular immunity is achieved by a Pickering emulsion formulation that allows pliability and mobility of loaded antigens.
- Herman F. Staats
- & David J. Burkhart
-