Ubiquitylation articles within Nature Communications

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• Article | 06 September 2011

  Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling

  Transforming growth factor-β blocks the activation of pro-inflammatory cytokines, in part by the degradation of Myd88. This study shows that smad ubiquitin regulator proteins are shown to mediate the destruction of Myd8 and are therefore required for the anti-inflammatory effects of transforming growth factor-β.

  • Youn Sook Lee
  • , Jin Seok Park
  •  & Seok Hee Park

• Article | 02 August 2011

  Regulation of MITF stability by the USP13 deubiquitinase

  MITF is a transcription factor required for melanocyte development, which is activated in some melanomas. Zhao and colleagues show that USP13 removes ubiquitin from MITF, stabilizes MITF protein levels and enhances colony formation, suggesting that USP13 may be a therapeutic target in melanoma.

  • Xiansi Zhao
  • , Brian Fiske
  •  & David E Fisher

• Article
  31 May 2011 | Open Access

  TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer

  TGFβ can function as both a tumour suppressor and tumour promoter under different cellular contexts. Here, the cleavage product of the TGFβ type I receptor is shown to be generated in a TGFβ-dependent manner, and can induce the expression of genes involved in tumour cell invasion.

  • Yabing Mu
  • , Reshma Sundar
  •  & Marene Landström

• Article
  08 February 2011 | Open Access

  The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice

  Post-translational modifications are important in regulating protein function and turnover, and Ufm1 is part of a recently identified protein modification system. In this study, the authors show that Uba5, a component of the Ufm1 system, is important for regulating haematopoiesis and the differentiation of erythroid cells.

  • Kanako Tatsumi
  • , Harumi Yamamoto-Mukai
  •  & Masaaki Komatsu

• Article
  08 February 2011 | Open Access

  CSN-mediated deneddylation differentially modulates Ci¹⁵⁵ proteolysis to promote Hedgehog signalling responses

  Hedgehog signalling gradients are required for proper wing formation inDrosophila, and Hedgehog is known to regulate the cubitus interruptus transcription factor. Here, the authors show that the COP9 signalosome has a critical role in translating a Hedgehog gradient into a cubitus interruptus gradient.

  • June-Tai Wu
  • , Wei-Hsiang Lin
  •  & Cheng-Ting Chien