Tumour-necrosis factors articles within Nature

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  • Article |

    NEDD4-binding protein 1 (N4BP1) is identified as a suppressor of cytokine production that is inactivated by caspase-8, which provides insight into the mechanisms underlying the immunodeficiency caused by mutations in FADD and caspase-8.

    • Alexander D. Gitlin
    • , Klaus Heger
    •  & Vishva M. Dixit

  • Letter |

    Progestins, used in hormone replacement therapy and contraceptives, have been suggested to promote the development of breast cancer. These authors show that the ability of progestins to induce mammary tumours in mouse models is mediated by RANKL (receptor activator of NF-KB ligand). Inhibition of RANKL could reduce tumorigenesis in hormone-induced and other mouse mammary gland tumour models, suggesting a new therapeutic approach.

    • Eva Gonzalez-Suarez
    • , Allison P. Jacob
    •  & William C. Dougall

  • Letter |

    Progestins, used in contraceptives and hormone replacement therapy, have been linked to breast cancer. These authors provide a mechanistic basis for this association. They show in a mouse model that synthetic progestins can promote mammary tumour formation by inducing RANKL (receptor activator of NF-KB ligand), which acts on mammary epithelial cells through the RANKL receptor RANK.

    • Daniel Schramek
    • , Andreas Leibbrandt
    •  & Josef M. Penninger

  • Letter |

    In a mouse model of prostate cancer it is shown that infiltrating B cells promote tumorigenesis by secreting lymphotoxin. Lymphotoxin accelerates the emergence of castration-resistant prostate tumours in this model. Interfering with this pathway may offer therapeutic strategies for androgen-independent prostate cancer.

    • Massimo Ammirante
    • , Jun-Li Luo
    •  & Michael Karin

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