Research Highlight |
Featured
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Opinion |
Reproducibility of research and preclinical validation: problems and solutions
There is much concern in the literature over the lack of reproducibility of many scientific reports. In this Perspective, the authors discuss how cognitive biases in research and flaws in the academic incentive system also contribute to the publication of immature results. The authors suggest some changes to the grant submission and funding system that could further improve the reproducibility of research findings.
- Lajos Pusztai
- , Christos Hatzis
- & Fabrice Andre
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News & Views |
Any surprises from selective oestrogen-receptor modulators?
The marriage of medicinal chemistry, molecular biology and medicine is perhaps best exemplified by the evolution of selective oestrogen-receptor modulators (SERMs). Translational studies might be useful for predicting the myriad clinical responses to SERMs, contributing to improvements in women's health.
- V. Craig Jordan
The treatment bug—fighting cancer with bacterial infection
PI3Kδ inhibition lifts the breaks on antitumour immunity
ACVR1 mutations—a key piece in paediatric diffuse glioma
Nanotechnology targets cancer cells