Targeting BRAF has revolutionized the treatment of melanoma but sooner or later resistance to these treatments develops. Now, in biopsies from patients with melanoma, Ma et al., have reported that samples of tumours treated with BRAF inhibitors showed increased levels of autophagy compared with baseline. Combined treatment with BRAF and autophagy inhibitors promoted tumour regression in xenografts originally resistant to BRAF inhibition.
References
Ma, X.-H. et al. Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma. J. Clin. Invest. 124, 1406–1417 (2014)
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Inhibiting autophagy to fight BRAF resistance. Nat Rev Clin Oncol 11, 240 (2014). https://doi.org/10.1038/nrclinonc.2014.50
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DOI: https://doi.org/10.1038/nrclinonc.2014.50
