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| Open AccessFBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradation
- Ya Li
- , Caojian Zuo
- & Lidong Cai
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Article
| Open AccessThe heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations
- Yangyang Feng
- , Ming Zhao
- & Chu-Xia Deng
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Article
| Open AccessActivation of GPER1 in macrophages ameliorates UUO-induced renal fibrosis
- Lin Xie
- , Ye Cheng
- & Xiangchen Gu
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Article
| Open AccessSAA suppresses α-PD-1 induced anti-tumor immunity by driving TH2 polarization in lung adenocarcinoma
- Xin Wang
- , Shaodi Wen
- & Bo Shen
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| Open AccessSalicylate induces AMPK and inhibits c-MYC to activate a NRF2/ARE/miR-34a/b/c cascade resulting in suppression of colorectal cancer metastasis
- Chunfeng Liu
- , Matjaz Rokavec
- & Heiko Hermeking
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Review Article
| Open AccessMacrophage polarization and metabolism in atherosclerosis
- Pengbo Hou
- , Jiankai Fang
- & Gerry Melino
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Article
| Open AccessLAIR1 drives glioma progression by nuclear focal adhesion kinase dependent expressions of cyclin D1 and immunosuppressive chemokines/cytokines
- Xiaoqian Wei
- , Shushan Pan
- & Huanli Xu
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Article
| Open AccessHepatic T-cell senescence and exhaustion are implicated in the progression of fatty liver disease in patients with type 2 diabetes and mouse model with nonalcoholic steatohepatitis
- Byeong Chang Sim
- , Yea Eun Kang
- & Hyon-Seung Yi
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Article
| Open AccessNPM promotes hepatotoxin-induced fibrosis by inhibiting ROS-induced apoptosis of hepatic stellate cells and upregulating lncMIAT-induced TGF-β2
- Xue Ding
- , Xin-Le Zhu
- & Song-Lin Shi
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Article
| Open AccessHSF-1/miR-145-5p transcriptional axis enhances hyperthermic intraperitoneal chemotherapy efficacy on peritoneal ovarian carcinosis
- Silvia Di Agostino
- , Valeria Canu
- & Giovanni Blandino
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Article
| Open AccessJUN-induced super-enhancer RNA forms R-loop to promote nasopharyngeal carcinoma metastasis
- Qunying Jia
- , Yuan Tan
- & Faqin Tang
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Article
| Open AccessHNF4A-BAP31-VDAC1 axis synchronously regulates cell proliferation and ferroptosis in gastric cancer
- Qingqing Zhou
- , Tengfei Liu
- & Jun Zhang
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Article
| Open AccessInterferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcome
- Robert Y. S. Cheng
- , Lisa A. Ridnour
- & David A. Wink
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Article
| Open AccessPRR15 deficiency facilitates malignant progression by mediating PI3K/Akt signaling and predicts clinical prognosis in triple-negative rather than non-triple-negative breast cancer
- Fengzhu Guo
- , Jialu Ma
- & Binghe Xu
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Article
| Open AccessHOXB3 drives WNT-activation associated progression in castration-resistant prostate cancer
- Shimiao Zhu
- , Zhao Yang
- & Yuanjie Niu
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Article
| Open AccessLongitudinal efficacy and toxicity of SARS-CoV-2 vaccination in cancer patients treated with immunotherapy
- Pavlina Spiliopoulou
- , Helena J. Janse van Rensburg
- & Lillian L. Siu
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Article
| Open AccessResveratrol rescues cutaneous radiation-induced DNA damage via a novel AMPK/SIRT7/HMGB1 regulatory axis
- Yi Jin
- , Xingyuan Liu
- & Liang Zhou
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Article
| Open AccessTumor immune microenvironment and immunotherapy efficacy in BRAF mutation non-small-cell lung cancer
- Hui Li
- , Yongchang Zhang
- & Yun Fan
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Article
| Open AccessGlucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy
- Li Liu
- , Shanshan Han
- & Ingrid Herr
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Article
| Open AccessIdarubicin combats abiraterone and enzalutamide resistance in prostate cells via targeting XPA protein
- Ying Zhang
- , Wei Wei
- & Changlin Li
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Article
| Open AccessTargeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Abdelrahman Y. Fouda
- , Zhimin Xu
- & Ruth B. Caldwell
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Article
| Open AccessHigh-content imaging of human hepatic spheroids for researching the mechanism of duloxetine-induced hepatotoxicity
- Juan Liu
- , Ruihong Li
- & Yunfang Wang
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Article
| Open AccessInnovative multidimensional models in a high-throughput-format for different cell types of endocrine origin
- Stefan Bornstein
- , Igor Shapiro
- & Constanze Hantel
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Article
| Open AccessIdentification of an Epi-metabolic dependency on EHMT2/G9a in T-cell acute lymphoblastic leukemia
- Anna Montanaro
- , Samuel Kitara
- & Giovanni Roti
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Article
| Open AccessDedifferentiation-mediated stem cell niche maintenance in early-stage ductal carcinoma in situ progression: insights from a multiscale modeling study
- Joseph D. Butner
- , Prashant Dogra
- & Zhihui Wang
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Article
| Open AccessPOU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulating HIF1A signaling pathway
- Wenjing Xiao
- , Wei Geng
- & Yang Jin
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Article
| Open AccessTargeted CUL4A inhibition synergizes with cisplatin to yield long-term survival in models of head and neck squamous cell carcinoma through a DDB2-mediated mechanism
- Trace M. Jones
- , Claudia M. Espitia
- & Steffan T. Nawrocki
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Article
| Open AccessHucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis
- Youwen Tan
- , Yan Huang
- & Yongmin Yan
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Article
| Open AccessLeptin secreted from testicular microenvironment modulates hedgehog signaling to augment the endogenous function of Leydig cells
- Himanshu Arora
- , Rehana Qureshi
- & Ranjith Ramasamy
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Article
| Open AccessLong non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1α/VEGF signaling
- Huamei Wei
- , Zuoming Xu
- & Jian Pu
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Article
| Open AccessEpimedium protects against dyszoospermia in mice with Pex3 knockout by exerting antioxidant effects and regulating the expression level of P16
- Haiyang Zhao
- , Tingting Zhao
- & Yun Qian
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Review Article
| Open AccessExtracellular vesicles in ovarian cancer chemoresistance, metastasis, and immune evasion
- Wanjia Tian
- , Ningjing Lei
- & Lei Chang
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Article
| Open AccessThe BH3-only protein NOXA serves as an independent predictor of breast cancer patient survival and defines susceptibility to microtubule targeting agents
- Gerlinde Karbon
- , Manuel D. Haschka
- & Andreas Villunger
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Article
| Open AccessLong non-coding RNA HOMER3-AS1 drives hepatocellular carcinoma progression via modulating the behaviors of both tumor cells and macrophages
- Jian Pu
- , Wenchuan Li
- & Huamei Wei
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Article
| Open AccessMolecular and histological traits of reduced lysosomal acid lipase activity in the fatty liver
- Simone Carotti
- , Daniele Lettieri-Barbato
- & Umberto Vespasiani-Gentilucci
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Article
| Open AccessCardiac Wnt5a and Wnt11 promote fibrosis by the crosstalk of FZD5 and EGFR signaling under pressure overload
- Yan Zou
- , Le Pan
- & Junbo Ge
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Article
| Open AccessAutophagic secretion of HMGB1 from cancer-associated fibroblasts promotes metastatic potential of non-small cell lung cancer cells via NFκB signaling
- Yinghui Ren
- , Limin Cao
- & Ke Xu
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Article
| Open AccessSelective degradation of AR-V7 to overcome castration resistance of prostate cancer
- Yuan Liu
- , Cuifu Yu
- & Hongbiao Huang
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Article
| Open AccessmiR-526b-3p inhibits lung cancer cisplatin-resistance and metastasis by inhibiting STAT3-promoted PD-L1
- Kuan-bing Chen
- , Wei Yang
- & Ai-jun Lin
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Article
| Open AccessClinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models
- Michelle P. Clark
- , Thao Huynh
- & Gregor Ebert
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Review Article
| Open AccessEmerging understanding of apoptosis in mediating mesenchymal stem cell therapy
- Yu Fu
- , Bingdong Sui
- & Xuefeng Hu
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Article
| Open AccessTargeting epigenetic modulation of cholesterol synthesis as a therapeutic strategy for head and neck squamous cell carcinoma
- Xing Xu
- , Jun Chen
- & Xu Wang
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| Open AccessInterrogation of gender disparity uncovers androgen receptor as the transcriptional activator for oncogenic miR-125b in gastric cancer
- Ben Liu
- , Meng Zhou
- & Kexin Chen
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Article
| Open AccessPermissive effect of GSK3β on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease
- Bohan Chen
- , Pei Wang
- & Rujun Gong
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Article
| Open AccessThe deubiquitinating enzyme USP15 stabilizes ERα and promotes breast cancer progression
- Xiaohong Xia
- , Chuyi Huang
- & Hongbiao Huang
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Article
| Open AccessA protective role for autophagy in vitiligo
- Emanuela Bastonini
- , Daniela Kovacs
- & Mauro Picardo
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Article
| Open AccessFoxP3-miR-150-5p/3p suppresses ovarian tumorigenesis via an IGF1R/IRS1 pathway feedback loop
- Qinkai Zhang
- , Xunzhu Zhou
- & Jianmin Wu
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Article
| Open AccessAkt kinase LANCL2 functions as a key driver in EGFR-mutant lung adenocarcinoma tumorigenesis
- Yuqing Lou
- , Jianlin Xu
- & Baohui Han
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Article
| Open AccessGNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner
- Zhizhou Xia
- , Xiuli Zhang
- & Ruibao Ren