Featured
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Letter |
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
The nuclear receptors REV-ERB-α and REV-ERB-β are indispensible for the coordination of circadian rhythm and metabolism; mice without these nuclear receptors show disrupted circadian expression of core circadian clock and lipid homeostatic gene networks.
- Han Cho
- , Xuan Zhao
- & Ronald M. Evans
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Letter |
Transcription factor PIF4 controls the thermosensory activation of flowering
A novel mechanism by which warming temperatures can directly activate flowering in the model plant Arabidopsis thaliana.
- S. Vinod Kumar
- , Doris Lucyshyn
- & Philip A. Wigge
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Letter |
Maternal and paternal genomes contribute equally to the transcriptome of early plant embryos
Transcriptome sequencing and analysis of hybrid embryos show that in contrast to early animal embryogenesis, early plant embryogenesis is mostly under zygotic control.
- Michael D. Nodine
- & David P. Bartel
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Article |
The evolution of gene expression levels in mammalian organs
- David Brawand
- , Magali Soumillon
- & Henrik Kaessmann
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Editorial |
More than teeth
The bizarre-looking naked mole rat is a worthy member of the genome club.
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Letter
| Open AccessGenome sequencing reveals insights into physiology and longevity of the naked mole rat
- Eun Bae Kim
- , Xiaodong Fang
- & Vadim N. Gladyshev
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Letter |
Transcriptomic analysis of avian digits reveals conserved and derived digit identities in birds
- Zhe Wang
- , Rebecca L. Young
- & Günter P. Wagner
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Article |
The developmental transcriptome of Drosophila melanogaster
As part of the modENCODE initiative, which aims to characterize functional DNA elements in D. melanogaster and C. elegans, this study uses RNA-Seq, tiling microarrays and cDNA sequencing to explore the transcriptome in 30 distinct developmental stages of the fruitfly. Among the results are scores of new genes, coding and non-coding transcripts, as well as splicing and editing events.
- Brenton R. Graveley
- , Angela N. Brooks
- & Susan E. Celniker
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Letter |
Transcriptome genetics using second generation sequencing in a Caucasian population
Here, sequencing has been used to characterize the mRNA fraction of the transcriptome in Caucasian individuals, to provide a fine-scale view of transcriptomes and to identify genetic variants that affect alternative splicing. Measuring allele-specific expression identified rare expression quantitative trait loci (eQTLs) and allelic differences in transcript structure, revealing new properties of genetic effects on the transcriptome.
- Stephen B. Montgomery
- , Micha Sammeth
- & Emmanouil T. Dermitzakis
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Article |
The primary transcriptome of the major human pathogen Helicobacter pylori
The transcriptome of Helicobacter pylori, an important human pathogen involved in gastric ulcers and cancer, is presented. The approach establishes a model for mapping and annotating the primary transcriptomes of many living species.
- Cynthia M. Sharma
- , Steve Hoffmann
- & Jörg Vogel