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| Open AccessIn vitro and in vivo comparison of the immunotoxicity of single- and multi-layered graphene oxides with or without pluronic F-127
- Young Chol Cho
- , Pyo June Pak
- & Namhyun Chung
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| Open AccessFunctional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro cholestatic model
- Xuan Ni
- , Yimeng Gao
- & Guoyu Pan
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| Open AccessSoluble P-selectin rescues viper venom–induced mortality through anti-inflammatory properties and PSGL-1 pathway-mediated correction of hemostasis
- Der-Shan Sun
- , Pei-Hsun Ho
- & Hsin-Hou Chang
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| Open AccessEstablishment of a translational endothelial cell model using directed differentiation of induced pluripotent stem cells from Cynomolgus monkey
- Eva C. Thoma
- , Tobias Heckel
- & Christoph Patsch
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| Open AccessHepatic 3D spheroid models for the detection and study of compounds with cholestatic liability
- Delilah F. G. Hendriks
- , Lisa Fredriksson Puigvert
- & Magnus Ingelman-Sundberg
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| Open AccessVildagliptin and its metabolite M20.7 induce the expression of S100A8 and S100A9 in human hepatoma HepG2 and leukemia HL-60 cells
- Mitsutoshi Asakura
- , Fumika Karaki
- & Ryoichi Fujiwara
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| Open AccesscAMP-PKA-CaMKII signaling pathway is involved in aggravated cardiotoxicity during Fuzi and Beimu Combination Treatment of Experimental Pulmonary Hypertension
- Pengwei Zhuang
- , Yingying Huang
- & Jinao Duan
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| Open AccessMechanism of metamifop inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in Echinochloa crus-galli
- Xiangdong Xia
- , Wenjie Tang
- & Jianhong Li
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| Open AccessSynthesis of Mg-Fe-Cl hydrotalcite-like nanoplatelets as an oral phosphate binder: evaluations of phosphorus intercalation activity and cellular cytotoxicity
- Yung-Feng Lung
- , Ying-Sui Sun
- & Her-Hsiung Huang
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| Open AccessOxidative stress-mediated intrinsic apoptosis in human promyelocytic leukemia HL-60 cells induced by organic arsenicals
- Xiao-Yang Fan
- , Xin-You Chen
- & Yi Liu
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| Open AccessHuman Food Safety Implications of Variation in Food Animal Drug Metabolism
- Zhoumeng Lin
- , Christopher I. Vahl
- & Jim E. Riviere
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| Open AccessEfficacy of Indian polyvalent snake antivenoms against Sri Lankan snake venoms: lethality studies or clinically focussed in vitro studies
- Kalana Maduwage
- , Anjana Silva
- & Geoffrey K. Isbister
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Article
| Open AccessDrug vaping applied to cannabis: Is “Cannavaping” a therapeutic alternative to marijuana?
- Vincent Varlet
- , Nicolas Concha-Lozano
- & Christian Giroud
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| Open AccessLevetiracetam mitigates doxorubicin-induced DNA and synaptic damage in neurons
- Jose Felix Moruno Manchon
- , Yuri Dabaghian
- & Andrey S. Tsvetkov
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| Open AccessCharacterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
- Catherine C. Bell
- , Delilah F. G. Hendriks
- & Magnus Ingelman-Sundberg
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Article
| Open AccessInduction of P-glycoprotein expression and activity by Aconitum alkaloids: Implication for clinical drug–drug interactions
- Jinjun Wu
- , Na Lin
- & Linlin Lu
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| Open AccessThe nematode Caenorhabditis elegans as a tool to predict chemical activity on mammalian development and identify mechanisms influencing toxicological outcome
- Philippa H. Harlow
- , Simon J. Perry
- & Anthony J. Flemming
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| Open AccessAccumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity
- Jin-Yong Lee
- , Maki Tokumoto
- & Masahiko Satoh
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| Open AccessBPA-Induced Deregulation Of Epigenetic Patterns: Effects On Female Zebrafish Reproduction
- Stefania Santangeli
- , Francesca Maradonna
- & Oliana Carnevali
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| Open AccessXeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells
- Hye-Min Kim
- , Ji-Woo Kim
- & Han-Jin Park
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| Open AccessA novel Hsp70 inhibitor prevents cell intoxication with the actin ADP-ribosylating Clostridium perfringens iota toxin
- Katharina Ernst
- , Markus Liebscher
- & Cordelia Schiene-Fischer
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| Open AccessLigand selectivity in tachykinin and natalisin neuropeptidergic systems of the honey bee parasitic mite Varroa destructor
- Hongbo Jiang
- , Donghun Kim
- & Yoonseong Park
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Article
| Open AccessMethadone-induced Damage to White Matter Integrity in Methadone Maintenance Patients: A Longitudinal Self-control DTI Study
- Wei Li
- , Qiang Li
- & Yijun Liu
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Article
| Open AccessAkbu-LAAO exhibits potent anti-tumor activity to HepG2 cells partially through produced H2O2 via TGF-β signal pathway
- Chunmei Guo
- , Shuqing Liu
- & Ming-Zhong Sun
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Article
| Open AccessAcetaminophen cytotoxicity is ameliorated in a human liver organotypic co-culture model
- Leonard J. Nelson
- , Maria Navarro
- & John N. Plevris
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| Open AccessTowards An Advanced Graphene-Based Magnetic Resonance Imaging Contrast Agent: Sub-acute Toxicity and Efficacy Studies in Small Animals
- Shruti Kanakia
- , Jimmy Toussaint
- & Balaji Sitharaman
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| Open AccessDevelopment and application of loop-mediated isothermal amplification for detecting the highly benzimidazole-resistant isolates in Sclerotinia sclerotiorum
- Ya Bing Duan
- , Ying Yang
- & Ming Guo Zhou
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Article
| Open AccessZebrafish Models for Human Acute Organophosphorus Poisoning
- Melissa Faria
- , Natàlia Garcia-Reyero
- & Demetrio Raldúa
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Article
| Open AccessParadoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo
- Ping Yang
- , Yunfei Zhao
- & Xiong Z. Ruan
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Article
| Open AccessMitochondrial ADP/ATP exchange inhibition: a novel off-target mechanism underlying ibipinabant-induced myotoxicity
- Tom J. J. Schirris
- , Tina Ritschel
- & Frans G. M. Russel
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Article
| Open AccessIncreased Acetylcholinesterase Expression in Bumble Bees During Neonicotinoid-Coated Corn Sowing
- Olivier Samson-Robert
- , Geneviève Labrie
- & Valérie Fournier
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| Open AccessPrediction of drug-induced nephrotoxicity and injury mechanisms with human induced pluripotent stem cell-derived cells and machine learning methods
- Karthikeyan Kandasamy
- , Jacqueline Kai Chin Chuah
- & Daniele Zink
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| Open AccessInhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice
- Ling-Lei Kong
- , Xiao-Mei zhuang
- & Hua Li
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Article
| Open AccessSerotonin Deficiency Exacerbates Acetaminophen-Induced Liver Toxicity In Mice
- Jingyao Zhang
- , Sidong Song
- & Chang Liu
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| Open AccessHyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression
- Guangfeng Zhao
- , Guijun Yan
- & Yali Hu
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| Open AccessReduction of intraarticular adhesion by topical application of colchicine following knee surgery in rabbits
- Yu Sun
- , Yuan Liang
- & Lianqi Yan
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| Open AccessOn-chip in vitro cell-network pre-clinical cardiac toxicity using spatiotemporal human cardiomyocyte measurement on a chip
- Tomoyuki Kaneko
- , Fumimasa Nomura
- & Kenji Yasuda
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Article
| Open AccessThe optimal concentration of topical hydroxycamptothecin in preventing intraarticular scar adhesion
- Yuan Liang
- , Yu Sun
- & Jinshan He
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| Open AccessA high-throughput three-dimensional cell migration assay for toxicity screening with mobile device-based macroscopic image analysis
- David M. Timm
- , Jianbo Chen
- & Glauco R. Souza
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| Open AccessTarget proteins of ganoderic acid DM provides clues to various pharmacological mechanisms
- Jie Liu
- , Kuniyoshi Shimizu
- & Ryuichiro Kondo
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| Open AccessArachidonic Acid Enhances Caffeine-Induced Cell Death via Caspase-Independent Cell Death
- Hidekazu Kuwayama
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| Open AccessCarcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice
- Seiji Takanashi
- , Kazuo Hara
- & Naoto Saito
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| Open AccessAssessment of Extracts from Red Yeast Rice for Herb-Drug Interaction by in-vitro and in-vivo assays
- Wai To Fung
- , G. Subramaniam
- & Pak Ho Henry Leung
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| Open AccessSystemic aminoglycosides are trafficked via endolymph into cochlear hair cells
- Hongzhe Li
- & Peter S. Steyger