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| Open AccessBipyrazone: a new HPPD-inhibiting herbicide in wheat
- Hengzhi Wang
- , Weitang Liu
- & Jinxin Wang
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| Open AccessGadolinium labelled nanoliposomes as the platform for MRI theranostics: in vitro safety study in liver cells and macrophages
- Pavlína Šimečková
- , František Hubatka
- & Jaroslav Turánek
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| Open AccessOxygen consumption rate of Caenorhabditis elegans as a high-throughput endpoint of toxicity testing using the Seahorse XFe96 Extracellular Flux Analyzer
- G. Du Preez
- , H. Fourie
- & V. Wepener
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| Open AccessCombined cardio-protective ability of syringic acid and resveratrol against isoproterenol induced cardio-toxicity in rats via attenuating NF-kB and TNF-α pathways
- Manjunatha S.
- , Althaf Hussain Shaik
- & Lakshmi Devi Kodidhela
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| Open AccessThalidomide Inhibits Human iPSC Mesendoderm Differentiation by Modulating CRBN-dependent Degradation of SALL4
- David G. Belair
- , Gang Lu
- & Kyle L. Kolaja
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| Open AccessQuzhou Fructus Aurantii Extract suppresses inflammation via regulation of MAPK, NF-κB, and AMPK signaling pathway
- Lili Li
- , Jiaoting Chen
- & Zhenqiang You
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| Open AccessTargeting redox metabolism: the perfect storm induced by acrylamide poisoning in the brain
- Demetrio Raldúa
- , Marta Casado
- & Benjamin Piña
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| Open AccessMitragynine, an euphoric compound inhibits hERG1a/1b channel current and upregulates the complexation of hERG1a-Hsp90 in HEK293-hERG1a/1b cells
- Yea Lu Tay
- , Azimah Amanah
- & Mei Lan Tan
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| Open AccessExacerbation of ozone-induced pulmonary and systemic effects by β2-adrenergic and/or glucocorticoid receptor agonist/s
- Andres R. Henriquez
- , Samantha J. Snow
- & Urmila P. Kodavanti
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| Open AccessIncreased heart fibrosis and acute infection in a murine Chagas disease model associated with organophosphorus pesticide metabolite exposure
- Dunia Margarita Medina-Buelvas
- , Elizabet Estrada-Muñiz
- & Libia Vega
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| Open AccessRapid maturation of the hepatic cell line Huh7 via CDK inhibition for PXR dependent CYP450 metabolism and induction
- Beyza Bulutoglu
- , Safak Mert
- & O. Berk Usta
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| Open AccessLack of effect of Imrecoxib, an innovative and moderate COX-2 inhibitor, on pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers
- Yani Liu
- , Rui Zhang
- & Shaojun Shi
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| Open AccessIn vitro nephrotoxicity and anticancer potency of newly synthesized cadmium complexes
- Selda Abyar
- , Ali Akbar Khandar
- & Manoe J. Janssen
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Article
| Open AccessAntileukemic activity of novel adenosine derivatives
- Anastazja Poczta
- , Aneta Rogalska
- & Agnieszka Marczak
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Article
| Open AccessEffects of cannabinoids on the development of chick embryos in ovo
- Sofia B. Gustafsson
- & Stig O. P. Jacobsson
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| Open AccessEffects of T-2 toxin on digestive enzyme activity, intestinal histopathology and growth in shrimp Litopenaeus vannamei
- Zhanrui Huang
- , Yaling Wang
- & Jian Zhao
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| Open AccessIn Vitro and In Vivo Evaluation of the Anticancer and Anti-inflammatory Activities of 2-Himachelen-7-ol isolated from Cedrus Libani
- Andree Elias
- , Wassim N. Shebaby
- & Robin I. Taleb
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Article
| Open AccessGram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor
- Cunyu Zhang
- , Katrina L. Creech
- & Timothy M. Willson
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Article
| Open AccessSelective cytotoxicity and antifungal properties of copper(II) and cobalt(II) complexes with imidazole-4-acetate anion or 1-allylimidazole
- Katarzyna Gałczyńska
- , Karol Ciepluch
- & Michał Arabski
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Article
| Open AccessOn the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships
- Christopher W. McAleer
- , Amy Pointon
- & Lorna Ewart
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Article
| Open AccessMicrobiota alter metabolism and mediate neurodevelopmental toxicity of 17β-estradiol
- Tara R. Catron
- , Adam Swank
- & Tamara Tal
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| Open AccessTranscriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome P450 (Cyp)3a11 gene
- Guncha Taneja
- , Suman Maity
- & Romi Ghose
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Article
| Open AccessToxicological testing of allogeneic secretome derived from peripheral mononuclear cells (APOSEC): a novel cell-free therapeutic agent in skin disease
- Silvio Wuschko
- , Alfred Gugerell
- & Hendrik J. Ankersmit
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| Open Access3D-QSAR, Docking, ADME/Tox studies on Flavone analogs reveal anticancer activity through Tankyrase inhibition
- Sarfaraz Alam
- & Feroz Khan
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| Open AccessEffect of Spheroidal Age on Sorafenib Diffusivity and Toxicity in a 3D HepG2 Spheroid Model
- Christoph Eilenberger
- , Mario Rothbauer
- & Seta Küpcü
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| Open AccessDMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro
- M. Verheijen
- , M. Lienhard
- & F. Caiment
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| Open AccessImpact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae
- Rob C. van Wijk
- , Elke H. J. Krekels
- & Herman P. Spaink
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| Open AccessHoney bees long-lasting locomotor deficits after exposure to the diamide chlorantraniliprole are accompanied by brain and muscular calcium channels alterations
- Aklesso Kadala
- , Mercédès Charreton
- & Claude Collet
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| Open AccessGreenhouse and field evaluation of a novel HPPD-inhibiting herbicide, QYM201, for weed control in wheat
- Fengwen Zhang
- , Shuang Bai
- & Jinxin Wang
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Article
| Open AccessVoltage-gated sodium channels from the bees Apis mellifera and Bombus terrestris are differentially modulated by pyrethroid insecticides
- Aklesso Kadala
- , Mercédès Charreton
- & Claude Collet
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Article
| Open AccessA 14-day repeat dose oral gavage range-finding study of a first-in-class CDI investigational antibiotic, in rats
- Katherine Sibley
- , Jayson Chen
- & Ramiz A. Boulos
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| Open AccessFXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis
- Rowan F. van Golen
- , Pim B. Olthof
- & Michal Heger
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Article
| Open AccessExogenous exosomes from mice with acetaminophen-induced liver injury promote toxicity in the recipient hepatocytes and mice
- Young-Eun Cho
- , Wonhyo Seo
- & Moon-Chang Baek
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| Open AccessAntiproliferative activities of the second-generation antipsychotic drug sertindole against breast cancers with a potential application for treatment of breast-to-brain metastases
- Wei Zhang
- , Cunlong Zhang
- & Yuyang Jiang
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| Open AccessToxic Effects of Size-tunable Gold Nanoparticles on Caenorhabditis elegans Development and Gene Regulation
- Chun-Chih Hu
- , Gong-Her Wu
- & Ta-Jen Yen
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| Open AccessReplacing the Draize eye test: Impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation
- C. Lotz
- , L. Kiesewetter
- & F. Groeber-Becker
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| Open AccessSimultaneous evaluation of anti-EGFR-induced tumour and adverse skin effects in a microfluidic human 3D co-culture model
- Juliane Hübner
- , Marian Raschke
- & Uwe Marx
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| Open AccessOn-chip spatiotemporal electrophysiological analysis of human stem cell derived cardiomyocytes enables quantitative assessment of proarrhythmia in drug development
- Yumiko Asahi
- , Tomoyo Hamada
- & Kenji Yasuda
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| Open AccessHuman tissue-engineered skeletal muscle: a novel 3D in vitro model for drug disposition and toxicity after intramuscular injection
- D. Gholobova
- , M. Gerard
- & L. Thorrez
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| Open AccessMetabolic network-based predictions of toxicant-induced metabolite changes in the laboratory rat
- Venkat R. Pannala
- , Martha L. Wall
- & Anders Wallqvist
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| Open AccessEvaluation of in vitro neuronal platforms as surrogates for in vivo whole brain systems
- Anna M. Belle
- , Heather A. Enright
- & Elizabeth K. Wheeler
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| Open AccessToxicological evaluation of convulsant and anticonvulsant drugs in human induced pluripotent stem cell-derived cortical neuronal networks using an MEA system
- A. Odawara
- , N. Matsuda
- & I. Suzuki
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| Open AccessCharacterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology
- Caroline R. Archer
- , Rebecca Sargeant
- & Amy Pointon
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Article
| Open AccessChemDIS-Mixture: an online tool for analyzing potential interaction effects of chemical mixtures
- Chun-Wei Tung
- , Chia-Chi Wang
- & Pinpin Lin
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Article
| Open AccessA genome-wide mutation analysis method enabling high-throughput identification of chemical mutagen signatures
- Shoji Matsumura
- , Yurika Fujita
- & Hiroshi Honda
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| Open AccessNMR-based Metabolomic Techniques Identify the Toxicity of Emodin in HepG2 Cells
- Chang Chen
- , Jian Gao
- & An Liu
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| Open AccessEffect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1
- Saki Omote
- , Natsumi Matsuoka
- & Ikumi Tamai
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| Open AccessEvaluation of weed control efficacy and crop safety of the new HPPD-inhibiting herbicide-QYR301
- Hengzhi Wang
- , Weitang Liu
- & Jinxin Wang
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Article
| Open AccessA rapid and nondestructive protocol for whole-mount bone staining of small fish and Xenopus
- Hiromi Sakata-Haga
- , Maimi Uchishiba
- & Toshihisa Hatta