News & Views |
Featured
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News & Views |
Defined matrices bring IBD to 3D
An immune cell population enriched in inflamed gut tissue is shown to play a role in driving CD44+ intestinal organoid proliferation, while also regulating extracellular matrix deposition and remodelling in a synthetic hydrogel platform.
- Bauer L. LeSavage
- & Sarah C. Heilshorn
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Letter |
Recapitulating macro-scale tissue self-organization through organoid bioprinting
A 3D bioprinting approach has been developed to facilitate tissue morphogenesis by directly depositing organoid-forming stem cells in an extracellular matrix, with the ability to generate intestinal epithelia and branched vascular tissue constructs.
- Jonathan A. Brassard
- , Mike Nikolaev
- & Matthias P. Lutolf
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Article |
Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair
Wnt3a protein has been immobilized on a biocompatible bandage and is now shown to induce oriented asymmetric cell division of human skeletal stem cells and can also promote bone tissue repair in vivo.
- Yoshihisa Okuchi
- , Joshua Reeves
- & Shukry J. Habib
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Review Article |
Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases
This Review highlights approaches used to generate somatic cell-derived organoids for modelling epithelial tissue to understand disease progression and how they are employed in preclinical drug screening.
- Masayuki Fujii
- & Toshiro Sato
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Article |
Bioactive site-specifically modified proteins for 4D patterning of gel biomaterials
A modular approach of photoreversible patterning of macromolecules with high spatiotemporal resolution within hydrogels is employed to generate biomaterials with controllable cell activity through site-specific immobilization of proteins.
- Jared A. Shadish
- , Gabrielle M. Benuska
- & Cole A. DeForest
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Article |
Injectable tissue integrating networks from recombinant polypeptides with tunable order
A protein-based material with temperature-modulated mechanical properties and function is achieved by the rational incorporation of structural ordering and disordering elements into its polypeptide sequence.
- Stefan Roberts
- , Tyler S. Harmon
- & Ashutosh Chilkoti
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Editorial |
Regeneration gets physical
As the role of biophysical cues in regulating cell behaviour is increasingly understood, more evidence in the field of bioengineering indicates how such signals can affect cells and tissues.
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News & Views |
Method in the madness of fibrosis
Blocking the growth of new blood vessels has been shown to alter fibrosis in livers in a disease stage-specific manner. In vitro models of fibrosis were developed to understand this process, highlighting the role of environmental mechanics.
- Geoffrey C. Gurtner
- & Jagannath Padmanabhan
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Article |
Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis
Angiogenesis has been implicated in fibrotic diseases of the liver. Here, the authors developed microniches that mimic angiogenesis during different stages of liver fibrosis, and demonstrate the role of mechanotransduction in fibrogenesis.
- Longwei Liu
- , Zhifeng You
- & Yanan Du
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Article |
Mechanical confinement regulates cartilage matrix formation by chondrocytes
The mechanical properties of biomaterials affect cell growth through mechanotransduction signals. Here, hydrogels with fast stress relaxation were developed and showed increased cartilage matrix formation by cartilage cells compared to slow relaxation hydrogels.
- Hong-pyo Lee
- , Luo Gu
- & Ovijit Chaudhuri
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Article |
Flexible shape-memory scaffold for minimally invasive delivery of functional tissues
Cardiac repair usually requires highly invasive interventional procedures. Here, the authors develop an injectable shape-memory cardiac patch and demonstrated its applicability in a myocardial infarction model.
- Miles Montgomery
- , Samad Ahadian
- & Milica Radisic
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Letter |
Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing
Heart-on-a-chip devices with integrated strain gauges for direct readout of tissue contractile strength allow for multiplexed drug-dose experiments and studies of functional maturation of cardiac tissue.
- Johan U. Lind
- , Travis A. Busbee
- & Kevin K. Parker
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News & Views |
Scalable vascularized implants
Biodegradable and perfusable scaffolds enable the fabrication of implantable, millimetre-scale cardiac and hepatic tissue models.
- Ying Zheng
- & Meredith A. Roberts
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News & Views |
Signals from within
A regenerative cardiac patch with integrated freestanding electrodes allows the electrical stimulation and recording of cardiomyocyte growth and activity, with on-demand drug delivery.
- Milica Radisic
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Article |
Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function
Integrating multifunctional electronics with engineered cardiac patches enables the recording of cellular electrical activities, and on-demand provision of electrical stimulation and release of drugs.
- Ron Feiner
- , Leeya Engel
- & Tal Dvir
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Article |
Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis
Biodegradable, perfusable scaffolds are able to generate both in vitro cardiac and hepatic vascularized tissue models and in vivo implants for direct surgical anastomosis.
- Boyang Zhang
- , Miles Montgomery
- & Milica Radisic
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Article |
Microstructural heterogeneity directs micromechanics and mechanobiology in native and engineered fibrocartilage
Tissue-engineered constructs with non-fibrous, proteoglycan-rich microdomains match the microstructural, micromechanical and mechanobiological properties of native fibrocartilaginous tissue.
- Woojin M. Han
- , Su-Jin Heo
- & Dawn M. Elliott
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News & Views |
Perfusable vascular networks
A rapid vascular casting approach that uses carbohydrate glass as a sacrificial template allows tissues to be built that can be kept alive for longer in the laboratory until needed for transplantation.
- Gabor Forgacs
Synthetic scaffold for pancreatic organoids
Assembled using DNA glue