Tissue engineering articles within Nature Genetics

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• Research Briefing | 04 November 2022

  Adult human kidney organoids: cellular origin and disease modeling

  Adult human kidney organoids or tubuloids are derived from an epithelial CD24⁺ subpopulation in the proximal nephron and can be utilized for advanced disease modeling of the most common hereditary kidney disease: autosomal dominant polycystic kidney disease.

• Letter | 18 January 2016

  A predictive computational framework for direct reprogramming between human cell types

  Owen Rackham, Jose Polo, Julian Gough and colleagues present a method, Mogrify, for predicting sets of transcription factors that can induce transdifferentiation between cell types. They show that Mogrify is able to predict known factors for published cell conversions and experimentally validate factors for two new conversions.

  • Owen J L Rackham
  • , Jaber Firas
  •  & Julian Gough