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| Open AccessImproved prediction of solvation free energies by machine-learning polarizable continuum solvation model
Accurate theoretical evaluation of solvation free energy is challenging. Here the authors introduce a machine-learning based polarizable continuum solvation approach to improve the accuracy of widely accepted continuum solvation models by almost one order of magnitude without additional computational costs.
- Amin Alibakhshi
- & Bernd Hartke
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Article
| Open AccessManifestations of metastable criticality in the long-range structure of model water glasses
The subtle connections between water’s supercooled liquid and glassy states are difficult to characterize. Gartner et al. suggest with MD simulations that the long-range structure of glassy water may reflect signatures of water’s debated second critical point in the supercooled liquid.
- Thomas E. Gartner III
- , Salvatore Torquato
- & Pablo G. Debenedetti
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Article
| Open AccessStructure and nature of ice XIX
Water’s phase diagram exhibits several hydrogen-disordered phases which become ordered upon cooling, but the behavior of ice VI is still debated. The authors, using high-pressure neutron diffraction, identify structural distortions that transform ice VI into ice XIX, here identified as a hydrogen disordered phase.
- Christoph G. Salzmann
- , John S. Loveday
- & Craig L. Bull
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| Open AccessA graph-based network for predicting chemical reaction pathways in solid-state materials synthesis
Predictive computational approaches are fundamental to accelerating solid-state inorganic synthesis. This work demonstrates a computational tractable approach constructed from available thermochemistry data and based on a graph-based network model for predicting solid-state inorganic reaction pathways.
- Matthew J. McDermott
- , Shyam S. Dwaraknath
- & Kristin A. Persson
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| Open AccessEquilibrium and non-equilibrium furanose selection in the ribose isomerisation network
Furanose species have a key role in the chemistry of life despite their instability over pyranose ones. The authors, through NMR characterization of the anomeric ratios at equilibrium and a non-equilibrium theoretical treatment, show that a steady temperature gradient, at temperatures relevant to the early Earth, favors furanose over pyranose isomers.
- Avinash Vicholous Dass
- , Thomas Georgelin
- & Francesco Piazza
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| Open AccessConfinement effects and acid strength in zeolites
The structure of water around Brønsted acid sites in zeolites is shown to influence their catalytic activity. Here the authors shed light on confinement effects in different pores zeolites/water interfaces acidic strength by means of ab-initio molecular dynamics and enhanced sampling metadynamics techniques.
- Emanuele Grifoni
- , GiovanniMaria Piccini
- & Michele Parrinello
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Article
| Open AccessA quantum heat engine driven by atomic collisions
Designing reliable nanoscale quantum-heat engines achieving high efficiency, high power and high stability is of fundamental and practical interest. Here, the authors report the realization of such a quantum machine using individual neutral Cs atoms in an atomic Rb bath, in which quantized heat exchange via inelastic spin-exchange collisions is controlled at the level of single quanta.
- Quentin Bouton
- , Jens Nettersheim
- & Artur Widera
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Article
| Open AccessMixing indistinguishable systems leads to a quantum Gibbs paradox
The Gibbs paradox stems from the entropy change upon mixing two gases. Here, by considering bosonic and fermionic statistics, the authors show that an observer unable to distinguish the particles’ spins assigns a greater entropy increase to the mixing process than is possible in classical physics.
- Benjamin Yadin
- , Benjamin Morris
- & Gerardo Adesso
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Article
| Open AccessThermodynamics of structure-forming systems
Structure-forming systems, such as chemical reaction networks, are usually described with the grand-canonical ensemble, but this may be inaccurate for small-sized systems. Here, the authors propose a canonical ensemble approach for closed structure-forming systems, showing its application to physical problems including the self-assembly of soft matter.
- Jan Korbel
- , Simon David Lindner
- & Stefan Thurner
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Article
| Open AccessThe tight Second Law inequality for coherent quantum systems and finite-size heat baths
Quantum versions of the second law of thermodynamics proposed so far required an infinite bath and ideal energy storage in order to be tight. Here, Łobejko loosens these requirements, proving a tight upper bound on the average work that can be extracted in a quantum scenario.
- Marcin Łobejko
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Article
| Open AccessMultiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems
Precisely tuning the genetic response to environmental stimuli is a key step in engineering synthetic biology systems. Here, the authors profile 8269 IPTG-induced promoters to deconstruct the relationship between sequence architecture and gene expression.
- Timothy C. Yu
- , Winnie L. Liu
- & Guillaume Urtecho
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Article
| Open AccessThe corona of a surface bubble promotes electrochemical reactions
Gas bubbles forming on the surface of an electrode, a phenomenon common to several industrial electrolytic processes, are usually perceived as inert, passivating entities. Here, the authors show that that this general assumption does not hold for gas bubbles masking anodes operating in water.
- Yan B. Vogel
- , Cameron W. Evans
- & Simone Ciampi
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Article
| Open AccessPhonon heat transport in cavity-mediated optomechanical nanoresonators
Heat flux is well understood on macroscopic scales, however when the system size is reduced, novel phenomena are induced by fluctuations. Here, the authors demonstrate phonon heat transport between two nanomechanical resonators coupled by cavity enhanced interactions exhibiting an oscillating heat flux.
- Cheng Yang
- , Xinrui Wei
- & Haibin Wu
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Article
| Open AccessArea law of noncritical ground states in 1D long-range interacting systems
The entanglement in non-critical ground states is conjectured to obey the area law, which is believed to arise from the short-range nature of interactions. Here the authors prove that the entanglement area law rigorously holds in one-dimensional systems even in the presence of long-range interactions.
- Tomotaka Kuwahara
- & Keiji Saito
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| Open AccessElectric field control of radiative heat transfer in a superconducting circuit
Quantum heat transport may be realized in superconducting circuits which has to rely on magnetic flux as a sole control parameter. Here, the authors report electric field tuning of photonic thermal conductance and observe heat flow oscillations in a magnetic field-free superconducting circuit.
- Olivier Maillet
- , Diego Subero
- & Jukka P. Pekola
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| Open AccessCryo-EM structures provide insight into how E. coli F1Fo ATP synthase accommodates symmetry mismatch
F1Fo ATP synthase consists of two coupled rotary molecular motors: the soluble ATPase F1 and the transmembrane Fo. Here, the authors present cryo-EM structures of E. coli ATP synthase in four discrete rotational sub-states at 3.1-3.4 Å resolution and observe a rotary sub-step of the Fo motor cring that reveals the mechanism of elastic coupling between the two rotary motors, which is essential for effective ATP synthesis.
- Meghna Sobti
- , James L. Walshe
- & Alastair G. Stewart
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Article
| Open AccessVibrational hierarchy leads to dual-phonon transport in low thermal conductivity crystals
Predicting thermal transport in low-thermal-conductivity (κL) materials is challenging. Here, the authors propose a dual-phonon theory, where normal phonons are treated using the Boltzmann thermal equation and diffuson-like phonons are treated within diffusion theory, yielding robust predictions of κL.
- Yixiu Luo
- , Xiaolong Yang
- & Xiulin Ruan
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| Open AccessPrediction of organic homolytic bond dissociation enthalpies at near chemical accuracy with sub-second computational cost
Bond dissociation enthalpies are key quantities in determining chemical reactivity, their computations with quantum mechanical methods being highly demanding. Here the authors develop a machine learning approach to calculate accurate dissociation enthalpies for organic molecules with sub-second computational cost.
- Peter C. St. John
- , Yanfei Guan
- & Robert S. Paton
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Article
| Open AccessThermodynamics of continuous non-Markovian feedback control
The second law of thermodynamics cannot be straightforwardly applied to systems with non-Markovian feedback control, and previous extensions to cover that regime have not been tested experimentally. Here, the authors bridge this gap using an optically levitated microsphere in a feedback-cooling system.
- Maxime Debiossac
- , David Grass
- & Nikolai Kiesel
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| Open AccessEfficiency fluctuations and noise induced refrigerator-to-heater transition in information engines
Information engines, also known as Maxwell demons, model the interplay between information transfer and work extraction in non-equilibrium systems or even living systems. Here, the authors show that noisy engines are more efficient then perfect ones in extracting work from information.
- Govind Paneru
- , Sandipan Dutta
- & Hyuk Kyu Pak
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| Open AccessStudying biomolecular folding and binding using temperature-jump mass spectrometry
Native mass spectrometry allows monitoring the folding and interactions of multiple coexisting species but its temporal resolution is traditionally limited. Here, the authors develop a temperature-jump electrospray source for mass spectrometry that enables fast kinetics experiments at different temperatures.
- Adrien Marchand
- , Martin F. Czar
- & Renato Zenobi
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Article
| Open AccessEukaryotic transcription factors can track and control their target genes using DNA antennas
To carry out their function, transcription factors must efficiently recognize specific DNA sequence targets, a complex problem in the context of eukaryotic chromatin. Here the authors use single-molecule biophysical experiments, statistical mechanical theory and bioinformatics analyses to conclude that interactions with non-target sequences near promoters serve to increase overall affinity and targeting efficiency.
- Milagros Castellanos
- , Nivin Mothi
- & Victor Muñoz
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| Open AccessReaching the ultimate energy resolution of a quantum detector
Quantum calorimeters can provide time-resolved measurement of single photons by converting them to detectable temperature changes. Here the authors demonstrate a calorimeter that reaches the lower bound of temperature resolution, determined by the coupling to its heat bath and associated fluctuations.
- Bayan Karimi
- , Fredrik Brange
- & Jukka P. Pekola
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| Open AccessChromatin fibers stabilize nucleosomes under torsional stress
Torsional stress is generated during DNA replication and transcription, however, the propagation of twist in condensed chromatin is poorly understood. Here the authors measure how force and torque impact chromatin fibers and find that the fibers fold into a left-handed superhelix that can be stabilized by positive torsion, suggesting that chromatin fibers stabilize nucleosomes under torsional stress.
- Artur Kaczmarczyk
- , He Meng
- & Nynke H. Dekker
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| Open AccessUnraveling the thermodynamic criteria for size-dependent spontaneous phase separation in soft porous crystals
Soft porous crystals hold big promise as functional nanoporous materials due to their stimuli responsive flexibility. Here, molecular dynamics simulations reveal a new type of spatial disorder in mesoscale crystals that helps to understand the size-dependency of their phase transition behavior.
- Sven M. J. Rogge
- , Michel Waroquier
- & Veronique Van Speybroeck
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Article
| Open AccessThermodynamic control of −1 programmed ribosomal frameshifting
Programmed ribosomal frameshifting (PRF) is an alternative translation strategy that causes controlled slippage of the ribosome along the mRNA, changing the sequence of the synthesized protein. Here the authors provide a thermodynamic framework that explains how mRNA sequence determines the efficiency of frameshifting.
- Lars V. Bock
- , Neva Caliskan
- & Helmut Grubmüller
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Article
| Open AccessThermodynamic efficiency in dissipative chemistry
Open chemical systems operate out of equilibrium, providing more opportunities than closed systems, but a theoretical framework to describe their performance is lacking. Here, the authors assess the efficiency of two classes of dissipative processes with a method applicable to any open chemical reaction network.
- Emanuele Penocchio
- , Riccardo Rao
- & Massimiliano Esposito
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| Open AccessMolecular mass growth through ring expansion in polycyclic aromatic hydrocarbons via radical–radical reactions
Polycyclic aromatic hydrocarbons (PAHs) represent key molecular building blocks in extraterrestrial environments but the understanding of their formation and growth in this environment has remained elusive. Here the authors reveal how naphthalene can be efficiently formed via rapid radical–radical reactions.
- Long Zhao
- , Ralf. I. Kaiser
- & Stanislaw F. Wnuk
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| Open AccessInferring broken detailed balance in the absence of observable currents
Non-equilibrium systems with hidden states are relevant for biological systems such as molecular motors. Here the authors introduce a method for quantifying irreversibility in such a system by exploiting the fluctuations in the waiting times of time series data.
- Ignacio A. Martínez
- , Gili Bisker
- & Juan M. R. Parrondo
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| Open AccessCorrelations as a resource in quantum thermodynamics
Correlations in quantum thermodynamics are usually regarded as a useful but expensive resource. Here, the authors prove that the work cost of generating multiple copies of a state is lower if the copies are correlated, pointing out at the irreversibility of the process in the single-shot regime.
- Facundo Sapienza
- , Federico Cerisola
- & Augusto J. Roncaglia
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| Open AccessRoom temperature electrofreezing of water yields a missing dense ice phase in the phase diagram
Water can crystallize in different ice polymorphs according to temperature and pressure conditions. Here the authors predict by molecular dynamics simulations a new ice phase spontaneously forming at room temperature under high pressure and high electric field.
- Weiduo Zhu
- , Yingying Huang
- & Xiao Cheng Zeng
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Article
| Open AccessCa2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif
Skeletal muscle voltage-gated Na+ channel (NaV1.4) activity is subject to calmodulin (CaM) mediated Ca2 +-dependent inactivation while cardiac NaV1.5 is not. Here authors use structural biology, binding and electrophysiology to parse the Ca2 +-dependent changes of CaM when bound to the NaV1.4.
- Jesse B. Yoder
- , Manu Ben-Johny
- & L. Mario Amzel
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| Open AccessQuantum absorption refrigerator with trapped ions
Studying quantum heat machines would extend our fundamental understanding of thermodynamics. Here, the authors report on absorption refrigeration within three normal modes of motion of a three-ion chain, studying performances using either thermal or squeezed states, also in the single-shot regime.
- Gleb Maslennikov
- , Shiqian Ding
- & Dzmitry Matsukevich
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| Open AccessIdentity crisis in alchemical space drives the entropic colloidal glass transition
Fluids may avoid crystallization via an underlying mechanism that remains hotly debated. Teich et al. show that hard polyhedral particles form glass because of the competition of local structural motifs, each of which is prevalent in crystals self-assembled from particles of closely related shapes.
- Erin G. Teich
- , Greg van Anders
- & Sharon C. Glotzer
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| Open AccessQuantum majorization and a complete set of entropic conditions for quantum thermodynamics
Similarly to entropy, majorization allows to quantify deviation from uniformity in a wide range of fields. In this paper, the authors use its generalization to the quantum realm to derive a complete set of necessary and sufficient conditions for thermal transformations of quantum states.
- Gilad Gour
- , David Jennings
- & Iman Marvian
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| Open AccessIn situ monitoring of molecular aggregation using circular dichroism
Molecular aggregation is a widespread and important process in physiological metabolism, but details regarding conformational changes during the process are hard to probe. Here, the authors use circular dichroism to monitor in-situ the conformational changes occurring during molecular aggregation.
- Haoke Zhang
- , Xiaoyan Zheng
- & Ben Zhong Tang
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| Open AccessSurfaces away from horizons are not thermodynamic
It has been conjectured that gravity may emerge from an entropic force arising on a holographic screen due to its purportedly intrinsic thermodynamic properties. Here, the authors test this conjecture by demonstrating that this key assumption of entropic force is inconsistent with general relativity.
- Zhi-Wei Wang
- & Samuel L. Braunstein
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| Open AccessSuppression of atom motion and metal deposition in mixed ionic electronic conductors
Mixed ionic–electronic conductors are limited by material decomposition. Here the authors reveal the mechanism for atom migration and deposition in Cu2–δ(S,Se) materials based on a critical chemical potential difference and propose electronically conducting, ion-blocking interfaces to enhance stability.
- Pengfei Qiu
- , Matthias T. Agne
- & G. Jeffrey Snyder
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| Open AccessEnergy-temperature uncertainty relation in quantum thermodynamics
The energy-temperature uncertainty relation bounds the precision of simultaneously estimating energy and temperature of a system in equilibrium. In this article, the authors provide a generalised version which is valid for both classical and quantum systems, and at arbitrary coupling to the environment.
- H. J. D. Miller
- & J. Anders
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Article
| Open AccessSpecial temperatures in frustrated ferromagnets
Competing interactions in frustrated magnets give rise to complex emergent phenomena, which challenge a full microscopic understanding but invite comparison to other systems. Bovo et al. find an analogy to classical gases and identify special temperatures that reveal fine details of the microscopic Hamiltonian.
- L. Bovo
- , M. Twengström
- & P. Henelius
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Article
| Open AccessEnhanced electrocaloric efficiency via energy recovery
Electrocaloric materials can be electrically driven to pump heat and hold promise for use in efficient solid-state refrigeration. Here, the authors demonstrate an approach to recycle recoverable energy from electrocaloric cycles, offering a method to enhance performance in electrocaloric refrigeration systems.
- E. Defay
- , R. Faye
- & N. D. Mathur
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Article
| Open AccessInformation-to-work conversion by Maxwell’s demon in a superconducting circuit quantum electrodynamical system
Maxwell’s demon is a hypothetical character that uses information about a system to reduce its entropy, highlighting the link between information and thermodynamic entropies. Here the authors experimentally realise a Maxwell's demon controlling a quantum system and explore how it affects thermodynamic laws.
- Y. Masuyama
- , K. Funo
- & Y. Nakamura
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Article
| Open AccessOscillating modes of driven colloids in overdamped systems
The motion of microparticles suspended in liquids is assumed to be dominated by viscous forces. Here, Berner et al. challenge this consensus by observing underdamped particle oscillations in a viscoelastic fluid and attributing it to the non-equilibrium fluctuations of liquid excited by particles.
- Johannes Berner
- , Boris Müller
- & Clemens Bechinger
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Article
| Open AccessIncreasing temperature of cooling granular gases
Granular gases—dilute systems composed of dissipatively colliding particles—exhibit anomalous dynamics and numerous surprising phenomena. Here, Brilliantov et al. show that the aggregation mechanism can induce increase of the gas temperature despite the fact that the total kinetic energy decreases.
- Nikolai V. Brilliantov
- , Arno Formella
- & Thorsten Pöschel
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Article
| Open AccessMeasurements of growing surface tension of amorphous–amorphous interfaces on approaching the colloidal glass transition
The existence of interfaces, separating distinct relaxing regions, has been predicted in glass theory, but a direct proof remains challenging due to the amorphous nature of glasses. Ganapathi et al. identify and measure the surface tension of these interfaces in bulk supercooled colloidal liquids.
- Divya Ganapathi
- , K. Hima Nagamanasa
- & Rajesh Ganapathy
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Article
| Open AccessAbnormal phase transition between two-dimensional high-density liquid crystal and low-density crystalline solid phases
Intermolecular interactions have a crucial role in the adsorption of molecules on a surface, however their role in promoting phase transitions is less well known. Here, the authors report an abnormal phase transition between a high-density liquid crystal and low-density solid in the case of carbon monoxide on Cu(111), driven by intermolecular interactions and entropy.
- Wenbin Li
- , Longjuan Kong
- & Lan Chen
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Article
| Open AccessThermodynamic insight into stimuli-responsive behaviour of soft porous crystals
Knowledge of the thermodynamic potential is crucial to characterize the macroscopic state of soft porous crystals. Here, the authors present a generalized thermodynamic approach to construct the Helmholtz free energy and identify the conditions under which a material becomes flexible.
- L. Vanduyfhuys
- , S. M. J. Rogge
- & V. Van Speybroeck
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Article
| Open AccessProtein conformational flexibility modulates kinetics and thermodynamics of drug binding
An understanding of the dynamics of drug binding and unbinding processes is important for drug discovery. Here, the authors give insights into the binding mechanism of small drug-like molecules to human Hsp90 by combining thermodynamics and kinetics studies as well as molecular dynamics simulations.
- M. Amaral
- , D. B. Kokh
- & M. Frech
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Article
| Open AccessGeneralized laws of thermodynamics in the presence of correlations
In presence of inter-system correlations, violations of the laws of thermodynamics become possible. Here, the authors develop a formalism redefining heat, work and thermodynamic laws in terms of quantum conditional entropy, which consistently generalize thermodynamics in correlated scenarios.
- Manabendra N. Bera
- , Arnau Riera
- & Andreas Winter