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Noncoding translation mitigation
Combining genome-wide CRISPR screens with massively parallel analyses of human and random DNA sequences reveal a unified mechanism for the surveillance and evolution of translation products from annotated noncoding DNA.
- Jordan S. Kesner
- , Ziheng Chen
- & Xuebing Wu
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Article
| Open AccessTwin study reveals non-heritable immune perturbations in multiple sclerosis
In monozygotic twins discordant for multiple sclerosis, the influence of genetic predisposition and environmental factors is determined using matched-pair analyses.
- Florian Ingelfinger
- , Lisa Ann Gerdes
- & Burkhard Becher
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Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
Multi-omics profiling of effects of SARS-CoV-2 and SARS-CoV on A549, a lung-derived human cell line, produces a dataset enabling identification of common and virus-specific mechanisms of infection.
- Alexey Stukalov
- , Virginie Girault
- & Andreas Pichlmair
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A multi-scale brain map derived from whole-brain volumetric reconstructions
Two complete volumetric reconstructions of the Caenorhabditis elegans main neuropil (the nerve ring) reveal multi-scale spatial organization that supports both conserved and variable circuitry, and enables the derivation of a modular structure–function model of the neuropil.
- Christopher A. Brittin
- , Steven J. Cook
- & Netta Cohen
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The functional proteome landscape of Escherichia coli
Thermal proteome profiling combined with a reverse genetics approach provides insights into the abundance and thermal stability of the global proteome of Escherichia coli.
- André Mateus
- , Johannes Hevler
- & Mikhail M. Savitski
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The proteome landscape of the kingdoms of life
An advanced proteomics workflow is used to identify 340,000 proteins from 100 taxonomically diverse species, providing a comparative view of proteomes across the evolutionary range.
- Johannes B. Müller
- , Philipp E. Geyer
- & Matthias Mann
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The online competition between pro- and anti-vaccination views
Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.
- Neil F. Johnson
- , Nicolas Velásquez
- & Yonatan Lupu
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Construction of a human cell landscape at single-cell level
Single-cell RNA sequencing is used to generate a dataset covering all major human organs in both adult and fetal stages, enabling comparison with similar datasets for mouse tissues.
- Xiaoping Han
- , Ziming Zhou
- & Guoji Guo
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Article
| Open AccessMulti-omics of the gut microbial ecosystem in inflammatory bowel diseases
The Inflammatory Bowel Disease Multi’omics Database includes longitudinal data encompassing a multitude of analyses of stool, blood and biopsies of more than 100 individuals, and provides a comprehensive description of host and microbial activities in inflammatory bowel diseases.
- Jason Lloyd-Price
- , Cesar Arze
- & Curtis Huttenhower
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Letter |
A global resource allocation strategy governs growth transition kinetics of Escherichia coli
A new approach to modelling bacterial growth removes the need to know kinetic parameters for metabolic and regulatory processes and can be used to model adaptive processes such as antibiotic responses and ecological dynamics.
- David W. Erickson
- , Severin J. Schink
- & Terence Hwa
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Letter |
Identifying specificity groups in the T cell receptor repertoire
The authors devise an algorithm that can cluster T cell receptor (TCR) sequences sharing the same specificity, predict the HLA restriction of these TCR clusters on the basis of subjects’ genotypes and help to identify specific peptide major histocompatibility complex ligands.
- Jacob Glanville
- , Huang Huang
- & Mark M. Davis
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Article
| Open AccessIntegrated genomic and molecular characterization of cervical cancer
This paper describes molecular subtypes of cervical cancers, including squamous cell carcinoma and adenocarcinoma clusters defined by HPV status and molecular features, and distinct molecular pathways that are activated in cervical carcinomas caused by different somatic alterations and HPV types.
- Robert D. Burk
- , Zigui Chen
- & David Mutch
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Letter |
Protein quality control at the inner nuclear membrane
A protein degradation pathway is found at the inner nuclear membrane that is distinct from, but complementary to, endoplasmic-reticulum-associated protein degradation, and which is mediated by the Asi protein complex; a genome-wide library screening of yeast identifies more than 20 substrates of this pathway, which is shown to target mislocalized integral membrane proteins for degradation.
- Anton Khmelinskii
- , Ewa Blaszczak
- & Michael Knop
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Coordination of bacterial proteome with metabolism by cyclic AMP signalling
Cyclic AMP, one of the earliest discovered and most intensely studied signalling molecules in molecular biology, is widely believed to signal the carbon status in mediating catabolite repression in bacteria; here a quantitative approach reveals a much broader physiological role for cAMP signalling, whereby it coordinates the allocation of proteomic resources with the global metabolic needs of the cell, including, for example, nitrogen or sulphur.
- Conghui You
- , Hiroyuki Okano
- & Terence Hwa
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