Synaptic plasticity

Synaptic plasticity is the biological process by which specific patterns of synaptic activity result in changes in synaptic strength and is thought to contribute to learning and memory. Both pre-synaptic and post-synaptic mechanisms can contribute to the expression of synaptic plasticity.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    In the hippocampus of adult mice, neuronally expressed interleukin-33 acts as a signal for microglial cell-mediated extracellular matrix remodelling, regulating synaptic plasticity and promoting memory consolidation.

    • Darran Yates
  • News and Views |

    Recent findings unveil a viral-like mechanism for the transmission of synaptic plasticity signals involving the activity-regulated cytoskeleton-associated protein (Arc). Arc forms capsid-like particles that package RNA and are transported across synapses. Here Erlendsson et al. present a high-resolution structural representation of Arc capsids, enabling deeper analysis of their function.

    • Vivian Budnik
    •  & Travis Thomson
    Nature Neuroscience 23, 153-154
  • Research Highlights |

    Two studies show that, compared with microglia in anaesthetized mice, microglia in awake mice show reduced surveillance owing to an increase in noradrenaline signalling.

    • Natasha Bray
  • Research Highlights |

    The encoding of salient events as memory traces involves the selective activation of specific neurons in the hippocampus and the inhibition of others, a process shown here to be regulated by GABAergic input from the nucleus incertus in the brainstem.

    • Sian Lewis