Synaptic plasticity articles within Nature Communications

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  • Article
    | Open Access

    Sorting nexin 27 (SNX27) regulates endosomal sorting of glutamate receptors. Loo et al.show that SNX27 is localized to recycling endosomes within dendritic spines where it interacts with glutamate receptors, allowing them to be shuttled to the postsynaptic membrane.

    • Li Shen Loo
    • , Ning Tang
    •  & Wanjin Hong

  • Article
    | Open Access

    Cholinergic signalling modulates learning and memory; however, its influence on learning-induced synaptic plasticity is less clear. Mitsushima et al.show that acetylcholine simultaneously strengthens both excitatory and inhibitory synapses onto CA1 pyramidal neurons following an inhibitory avoidance task.

    • Dai Mitsushima
    • , Akane Sano
    •  & Takuya Takahashi

  • Article |

    Slow-wave neural activity, which comprises up and down states, regulates long-term potentiation. Kruskal et al. show that endogenous neural circuit activity corresponding to up states acts as a potent and dynamic promoter of long-term potentiation.

    • Peter B. Kruskal
    • , Lucy Li
    •  & Jason N MacLean

  • Article |

    The protein RIMα is involved in targetting calcium channels to the active zones of presynaptic terminals. Here, the authors show that mice deficient in RIMα show reduced calcium influx in the cerebellar presynaptic terminals, which reduces neurotransmitter release probability and increases short-term plasticity.

    • Michael Kintscher
    • , Christian Wozny
    •  & Jörg Breustedt

  • Article
    | Open Access

    Motor cortex NMDA receptors have a key role in the acquisition of associative memories. Hasan et al. generate mice lacking NMDA receptor activity in the motor cortex and find that this impairs LTP, strengthening of synapses between somatosensory and motor cortices, and associative learning.

    • Mazahir T. Hasan
    • , Samuel Hernández-González
    •  & José M. Delgado-García

  • Article |

    The arrival of action potentials at nerve terminals often leads to synchronous neurotransmitter release. Medrihan and colleagues use electrophysiology on mouse hippocampal neurons to show that the vesicle protein Synapsin II promotes GABAergic asynchronous release by interacting with calcium channels.

    • Lucian Medrihan
    • , Fabrizia Cesca
    •  & Fabio Benfenati

  • Article |

    PAR-1 inDrosophilahas been identified as a key physiological tau kinase. Lee and colleagues perform genetic screens for regulators of PAR-1 and find that it is targeted for ubiquitination and degradation by the ubiquitin ligase complex SCF(Slimb), and that this pathway modulates synaptic morphology.

    • Seongsoo Lee
    • , Ji-Wu Wang
    •  & Bingwei Lu

  • Article |

    Synaptic tagging and capture describes thein vitro protein synthesis-dependent neuronal process where short-lasting forms of response potentiation are stabilised into long-lasting forms. Shires and colleagues find that this phenomenon also occurs in vivoin intact, living animals.

    • K.L. Shires
    • , B.M. Da Silva
    •  & S.J. Martin

  • Article |

    Adult neurogenesis in the mammalian brain is implicated in the storage and processing of memories. Vivaret al.label afferents to new dentate gyrus granule cells and find that they receive direct input from the perirhinal and lateral entorhinal cortex and that these inputs enable spatial pattern separation.

    • Carmen Vivar
    • , Michelle C. Potter
    •  & Henriette van Praag

  • Article
    | Open Access

    The ability of synthetic amyloid β-protein to bind to prion proteins and alter synaptic plasticity has been previously reported. Here the relevance of this binding is investigated in brains of Alzheimer's disease patients and the interaction is shown to be blocked by antibodies to two distinct regions of prion proteins.

    • Darragh B. Freir
    • , Andrew J. Nicoll
    •  & John Collinge

  • Article |

    Calorie restriction has been associated with increased life span and delayed decline of memory in animals, suggesting a role in neuronal plasticity. In this study, food restriction is demonstrated to enhance plasticity in the central nervous system and trigger the recovery from ocular deprivation in adulthood.

    • Maria Spolidoro
    • , Laura Baroncelli
    •  & Lamberto Maffei

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