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Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo
Findings from ex vivo studies suggest that gap junctional coupling contributes to hormone release in neuroendocrine/endocrine tissues. Here, the authors provide in vivo evidence that direct communication between adrenal chromaffin cells viagap junctions contributes to catecholamine secretion.
- Michel G. Desarménien
- , Carole Jourdan
- & Nathalie C. Guérineau
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Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress
The kinase ROCK1 has been implicated in apoptosis and other cellular functions. Here Gurkar et al. show that ROCK1 phosphorylates the autophagy regulator Beclin1, which activates autophagy by disrupting the association between Beclin-1 and Bcl-2.
- Aditi U. Gurkar
- , Kiki Chu
- & Sam W. Lee
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Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle
Endoplasmic reticulum (ER) stress is observed in diabetes and has been linked to insulin resistance in various tissues. Here, Koh and colleagues show the protein Tribbles 3, which is induced by ER stress and obesity in mice and humans, is an inhibitor of insulin signalling in skeletal muscle.
- Ho-Jin Koh
- , Taro Toyoda
- & Laurie J. Goodyear
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SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress
Centrosome duplication during cell division is controlled by the polo-like kinase PLK4. Nakamura et al. reveal how stress-activated protein kinase and the tumour suppressor p53 act together to regulate PLK4, and show that their combined loss in cancer cells leads to the appearance of supernumerary centrosomes.
- Takanori Nakamura
- , Haruo Saito
- & Mutsuhiro Takekawa
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| Open AccessOptimization of stress response through the nuclear receptor-mediated cortisol signalling network
Stress causes cortisol release and this is associated with the development of pathophysiology. Plant and colleagues use a computational model to reproduce the interaction of cortisol with its two nuclear receptors, and reveal how feed-forward and feed-back loops coordinate adaptation to repeated stress.
- Alexey Kolodkin
- , Nilgun Sahin
- & Nick Plant
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ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney
Cells must be able to sense and respond to changes in osmotic pressure, which can be lethal. Here, Naguro and colleagues reveal a role for the protein kinase ASK3 in sensing osmotic stress in the mouse kidney and show that ASK3 contributes to the regulation of blood pressure.
- Isao Naguro
- , Tsuyoshi Umeda
- & Hidenori Ichijo
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Organellar mechanosensitive channels in fission yeast regulate the hypo-osmotic shock response
Mechanosensitive channels are required to sense cell swelling in response to osmotic shock. Nakayamaet al.report that Msy1 and Msy2 are the fission yeast homologues of the bacterial mechanosensitive channel MscS, and are required for regulating intracellular calcium in response to cell swelling.
- Yoshitaka Nakayama
- , Kenjiro Yoshimura
- & Hidetoshi Iida
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Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins
In response to stress, yeast cells selectively translate proteins that can enhance cell survival. In this study, the authors find that tRNALEU(CAA)in yeast cells is modified in response to oxidative stress by a methyltransferase and this results in the selective translation of the mRNA for these genes.
- Clement T.Y. Chan
- , Yan Ling Joy Pang
- & Peter C. Dedon