Stomach articles within Nature

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• Article | 04 January 2017

  Wnt/β-catenin promotes gastric fundus specification in mice and humans

  Wnt signalling is shown to be required for specification of the gastric fundus in mice, and was used to develop human gastric organoids with functional fundic cell types.

  • Kyle W. McCracken
  • , Eitaro Aihara
  •  & James M. Wells

• Letter | 29 October 2014

  Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

  The in vitro generation, from pluripotent stem cells, of three-dimensional human gastric organoids (hGOs) that contain a physiological gastric epithelium comprising both progenitor and differentiated cell types, and have expected functional characteristics is described, as is modelling the pathophysiological response of the human stomach to Helicobacter pylori using these hGOs.

  • Kyle W. McCracken
  • , Emily M. Catá
  •  & James M. Wells