Stochastic networks articles within Nature

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• Letter | 19 June 2019

  A universal biomolecular integral feedback controller for robust perfect adaptation

  A synthetic gene circuit implementing an integral feedback topology is shown to achieve robust perfect adaptation in living cells--mathematical analysis proves this topology is necessary for adaptation in networks with noisy dynamics.

  • Stephanie K. Aoki
  • , Gabriele Lillacci
  •  & Mustafa Khammash

• Article | 20 November 2013

  Memory and modularity in cell-fate decision making

  This study shows that Bacillus subtilis switches from a solitary, motile lifestyle to a multicellular, sessile state in a random, memoryless fashion, but that the underlying gene network is buffered against its own stochastic variation to tightly time the reverse transition; thus bacteria keep track of time to force their progeny to cooperate during the earliest stage of multicellular growth.

  • Thomas M. Norman
  • , Nathan D. Lord
  •  & Richard Losick