Sterols articles within Nature Communications

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  • Article
    | Open Access

    Cholesterol lowering medication positively affects anti-cancer immune response, but the underpinning mechanism is not fully known. Here authors show that the effect is mediated by specific cholesterol binding motifs in STING, a key mediator of inflammation, via regulating its trafficking to Golgi.

    • Bao-cun Zhang
    • , Marlene F. Laursen
    •  & Martin R. Jakobsen

  • Article
    | Open Access

    Progesterone is used in recovery of cerebral ischemia however the mechanism of action is unknown. Authors report here that micromolar progesterone activates mouse cerebrovascular myocyte BK channels, involving two steroid binding sites.

    • Kelsey C. North
    • , Andrew A. Shaw
    •  & Alex M. Dopico

  • Article
    | Open Access

    Regulated cholesterol transport is essential for the maintenance of cellular cholesterol distribution and homeostasis, but tools to monitor this process are limited. Here, the authors develop a genetically encoded cholesterol biosensor and demonstrate its use for visualising cellular cholesterol distribution in various live cells in real time.

    • Dylan Hong Zheng Koh
    • , Tomoki Naito
    •  & Yasunori Saheki

  • Article
    | Open Access

    Cholesterol synthesis is highly oxygen consuming but how it is regulated by oxygen levels has not been clear. Here, Dickson et al. identify a HIF-independent, oxygen-sensing pathway for controlling cholesterol synthesis in human cells involving hypoxic-mediated degradation of SREBP2.

    • Anna S. Dickson
    • , Tekle Pauzaite
    •  & James A. Nathan

  • Article
    | Open Access

    Production of highly modified sterols, such as cholesterol, is essential to eukaryotic physiology but has not been yet reported for bacteria. Here, Lee et al. show that a marine myxobacterium produces cholesterol, and provide evidence for further downstream modifications in this and other bacterial species.

    • Alysha K. Lee
    • , Jeremy H. Wei
    •  & Paula V. Welander

  • Article
    | Open Access

    The yeast Saccharomyces cerevisiae is powerful for studying human G protein-coupled receptors as they can be coupled to its mating pathway. Here the authors engineer baker’s yeast to produce human sterols and show that vertebrate G protein coupled receptors are more sensitive in this membrane environment.

    • Björn D. M. Bean
    • , Colleen J. Mulvihill
    •  & Vincent J. J. Martin

  • Article
    | Open Access

    Although lipids are known to affect Hedgehog (Hh) signalling, the underlying mechanisms remain unclear. Here, the authors show that Canopy4 regulates membrane sterol lipid levels, with knockout mouse embryos exhibiting digit number changes and other Hh signalling-related developmental defects.

    • Megan Lo
    • , Amnon Sharir
    •  & Ophir D. Klein

  • Article
    | Open Access

    Hedgehog-Interacting Protein (HHIP) is the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling. Here, the authors report structures of the HHIP N- and C-terminal domains, both in complexes with glycosaminoglycans, providing insights into the molecular basis for SHH sequestration and inhibition.

    • Samuel C. Griffiths
    • , Rebekka A. Schwab
    •  & Christian Siebold

  • Article
    | Open Access

    The mechanisms governing cholesterol homeostasis remain incompletely understood. Here, the authors develop an integrative genomic strategy to identify MMAB, and enzyme in the adenosylcobalamin pathway, as a regulator of hepatic LDLR activity and cholesterol biosynthesis.

    • Leigh Goedeke
    • , Alberto Canfrán-Duque
    •  & Carlos Fernández-Hernando

  • Article
    | Open Access

    Cellular cholesterol levels are tightly regulated. Here, the authors show that the hedgehog signalling receptor PTCH is a cholesterol transporter. Reduction in PTCH activity leads to cellular cholesterol accumulation, changes in nuclear hormone receptor activity and fatty acid metabolism.

    • Carla E. Cadena del Castillo
    • , J. Thomas Hannich
    •  & Anne Spang

  • Article
    | Open Access

    Lysosomes play an important role in cellular LDL-cholesterol uptake. Here, the authors perform a genome-wide genetic screen for cholesterol regulators and identify C18orf8 as a conserved subunit of a trimeric Rab7 GEF that controls LDL trafficking and NPC1-dependent lysosomal cholesterol export.

    • Dick J. H. van den Boomen
    • , Agata Sienkiewicz
    •  & Paul J. Lehner

  • Article
    | Open Access

    Enhanced cholesterol biosynthesis is associated with cancer progression. Here the authors identify the nuclear receptor RORγ as a novel master regulator of cholesterol metabolism in triple negative breast cancer (TNBC) and find that RORγ small-molecule antagonists induce tumor regression in patient-derived xenografts and immunocompetent mouse models.

    • Demin Cai
    • , Junjian Wang
    •  & Hong-Wu Chen

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