Stereochemistry

Stereochemistry is the scientific concept that describes the relationship between chemical compounds which have the same molecular formula and identical functional groups but with different three dimensional arrangements of atoms. These molecules are known as stereoisomers and can have very different properties from one another, particularly when interacting with biological systems.

Latest Research and Reviews

News and Comment

  • News and Views |

    Strained boronate complexes have now been shown to enable an unprecedented cross-coupling reaction across a C–C σ-bond. Using this approach, highly functionalized cyclobutanes can be prepared with excellent stereocontrol from readily available reagents.

    • Alejandro Parra
    •  & Mariola Tortosa
    Nature Chemistry 11, 104-106
  • News and Views |

    Optimization of catalytic stereoselectivity for new substrates often requires a time consuming experimental process, and high-accuracy molecular modelling remains intractable for comprehensive virtual screening. Now, highly enantioselective rhodium hydrogenation catalysts have been identified using a rapid computational transition-state analysis protocol and then experimentally verified.

    • Daniel H. Ess
  • News and Views |

    The preparation of three-dimensional frameworks with multiple stereocentres from simple acyclic hydrocarbons represents a challenging transformation. Now, starting from simple and readily available reagents, formation of these complex targets can be achieved in just three catalytic transformations with high levels of stereocontrol.

    • Laura Castoldi
    •  & Vittorio Pace
    Nature Chemistry 10, 1081-1082
  • News and Views |

    Knots have been rigorously studied since the 1860s, but only in the past 30 years have they been made in the laboratory in molecular form. Now, the most complex small-molecule examples so far — a composite knot and an isomeric link, each with nine crossings — have been prepared.

    • Edward E. Fenlon
    Nature Chemistry 10, 1078-1079
  • Comments and Opinion |

    Louis Pasteur was a scientific giant of the nineteenth century, but, as Joseph Gal asks, was his most famous contribution to the understanding of chemistry — chirality — influenced more by his artistic talents?

    • Joseph Gal
    Nature Chemistry 9, 604-605
  • News and Views |

    Planar molecules may break mirror symmetry when aligned on a surface, but both right- and left-handed forms will be created. Starting with a single-handed precursor, chiral adsorbates of planar hydrocarbons with a single handedness are formed in on-surface reactions.

    • Karl-Heinz Ernst
    Nature Chemistry 9, 195-196