Enantioselective synthesis of chiral cyclobutanes via direct cycloaddition of C–C single bonds with C=C double bonds has remained an unmet challenge. Now, a photoelectrocatalytic system enabling asymmetric dehydrogenative [2+2] cycloaddition of alkyl ketones and alkenes has been developed.
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Tao, Y., Huang, C. & Lu, Q. Cycloaddition with asymmetric photoelectrocatalysis. Nat Catal 6, 1107–1108 (2023). https://doi.org/10.1038/s41929-023-01071-7
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DOI: https://doi.org/10.1038/s41929-023-01071-7
