Stem cells articles within Nature Communications

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  • Article
    | Open Access

    Membrane repair of myocytes is important to prevent such disease as muscular dystrophy but the properties of this repair are not well characterised. In this study, vitamin E is shown to be important in the repair of myocyte cell membranes in cultured cells and in intact muscle.

    • Amber C. Howard
    • , Anna K. McNeil
    •  & Paul L. McNeil

  • Article
    | Open Access

    During cell division, a cytoplasmic bridge—the midbody—forms between the nascent daughter cells, but it has been unclear under which conditions this is retained by a daughter cell or released. Now, Ettinger and colleagues show that midbody-release occurs more frequently in stem cells compared with cancer cells.

    • Andreas W. Ettinger
    • , Michaela Wilsch-Bräuninger
    •  & Wieland B. Huttner

  • Article |

    The fusion of satellite cells to muscle fibres during adult life is required for both muscle growth and regeneration but it is unknown whether non-muscle cells contribute to this process. Now, Dellavalle and colleagues show that pericytes, cells associated with the vasculature can contribute to both growth and regeneration of muscle fibres.

    • A. Dellavalle
    • , G. Maroli
    •  & G. Cossu

  • Article |

    The generation of human cell lines using somatic cell nuclear transfer has been difficult to achieve. In this study, Egliet al. show that while mouse eggs reprogram somatic cells within hours, human eggs arrest after nuclear transfer which may be due to a lack of genome transcription.

    • Dieter Egli
    • , Alice E. Chen
    •  & Kevin Eggan

  • Article |

    Recent technological advances have allowed the expansion of spermatogonial stem cellsin vitro; however, in vivo conditions are required for the full differentiation of the cells. In this study, an in vitroorgan culture system is developed that allows the differentiation of the germ cells in the laboratory.

    • Takuya Sato
    • , Kumiko Katagiri
    •  & Takehiko Ogawa

  • Article |

    Studying the physical interaction of stem cells with their niche has previously been difficult. Using a fluorescence-based reporter, Michelet al. are able to show that bone morphogenetic protein signalling occurs between Drosophilatestes germline stem cells and their niche and is via adherens junctions.

    • Marcus Michel
    • , Isabel Raabe
    •  & Christian Bökel

  • Article
    | Open Access

    Tissue regeneration is of great interest; however the number of times a given tissue can regenerate is unknown. Now, Eguchiet al. demonstrate that the lens of the Japanese newt—Cynops pyrrhogaster—can regenerate 18 times over a 16-year period, and that the new lenses are similar to those of control adult animals.

    • Goro Eguchi
    • , Yukiko Eguchi
    •  & Panagiotis A. Tsonis

  • Article
    | Open Access

    It has been proposed that stem cells use nonrandom chromosome segregation to avoid the accumulation of replication-induced mutations. Here, the authors examine intestinal epithelial stem cell division and show, using label exclusion and retention assays, that the cells segregate their chromosomes randomly.

    • Marion Escobar
    • , Pierre Nicolas
    •  & Catherine Legraverend

  • Article |

    When cultured as single cells, embryonic stem cells have low viability. Here, blebbistatin, a non-muscle myosin II inhibitor, is shown to enhance the cloning efficiency, viability and adhesion of both human embryonic stem cells and human induced pluripotent stem cellsin vitro.

    • Andrea Walker
    • , Hua Su
    •  & Noboru Sato

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