Matters Arising |
Featured
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Letter |
Dynamics of oligodendrocyte generation in multiple sclerosis
There are no new oligodendrocytes in potentially remyelinated multiple sclerosis shadow plaques, although oligodendrocyte generation is increased in the normal appearing white matter of patients with aggressive disease, informing the development of new therapies.
- Maggie S. Y. Yeung
- , Mehdi Djelloul
- & Jonas Frisén
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Article |
Cell diversity and network dynamics in photosensitive human brain organoids
Long-term cultures of human brain organoids display a high degree of cellular diversity, mature spontaneous neuronal networks and are sensitive to light.
- Giorgia Quadrato
- , Tuan Nguyen
- & Paola Arlotta
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Letter |
Corridors of migrating neurons in the human brain and their decline during infancy
- Nader Sanai
- , Thuhien Nguyen
- & Arturo Alvarez-Buylla
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Research Highlights |
How experience shapes the brain
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Letter |
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
- Amar Sahay
- , Kimberly N. Scobie
- & René Hen
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Research Highlights |
Brain fluid spurs stem cells
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Letter |
Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal
In the adult brain, neural stem cells (NSCs) and neural progenitor cells (NPCs) are maintained in the subventricular zone. There, the Notch protein regulates the identity and self-renewal of NSCs, while epidermal growth factor receptor (EGFR) affects NPC proliferation and migration. Now it is found that these signalling pathways interact to maintain the balance between NSC and NPC populations.
- Adan Aguirre
- , Maria E. Rubio
- & Vittorio Gallo
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Research Highlights |
Neuroimaging: Stem cells on screen
Ptbp1 deletion does not induce astrocyte-to-neuron conversion