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REM sleep promotes experience-dependent dendritic spine elimination in the mouse cortex
Sleep plays an important role in learning and memory. Here the authors show that experience dependent elimination of spines is attenuated by REM sleep deprivation.
- Yanmei Zhou
- , Cora Sau Wan Lai
- & Wen-Biao Gan
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Article
| Open Access
Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
The authors show that a subanesthetic dose of ketamine markedly elevate calcium signals in apical dendritic spines in the mouse prefrontal cortex. This effect is driven by a local-circuit mechanism that involves the suppression of somatostatin interneurons leading to dendritic disinhibition.
- Farhan Ali
- , Danielle M. Gerhard
- & Alex C. Kwan
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Article
| Open Access
Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory
Structural remodeling of dendritic spines is thought to be a mechanism of memory storage. Here, the authors look at how spine turnover and clustering predict future learning and memory performance, and see that a genetically modified mouse with enhanced spine turnover has enhanced learning.
- Adam C. Frank
- , Shan Huang
- & Alcino J. Silva
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Article
| Open Access
The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory
Learning and memory depend on the structural and functional plasticity of synapses. Reinhard et al. show that the calcium sensor Copine-6 is required for memory, controls spine structure by regulating Rac signalling, and through its modulation of actin, supports hippocampal LTP.
- Judith R. Reinhard
- , Alexander Kriz
- & Markus A. Ruegg
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Article
| Open Access
A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses
The development of chronic inflammatory pain is linked with functional and structural modifications in nociceptive synapses. Here the authors demonstrate that Kalrinin-7 forms an essential link between synaptic receptors and cytoskeletal elements to functionally modify spinal nociceptive synapses.
- Jianning Lu
- , Ceng Luo
- & Rohini Kuner
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Article
| Open Access
miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement
Long-term potentiation (LTP) is a form of synaptic plasticity that results in enhanced synaptic strength. Here, the authors demonstrate that miR-26a and miR-384-5p affect the maintenance, but not induction, of LTP as well as spine enlargement by regulating the expression of RSK3.
- Qin-Hua Gu
- , Danni Yu
- & Zheng Li
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Extracellular matrix inhibits structural and functional plasticity of dendritic spines in the adult visual cortex
Neuronal connectivity in the mature brain is stabilized by the extracellular matrix. This study shows that degradation of chondroitin sulfate proteoglycans in the matrix increases connectivity in the adult cortex by causing a large increase in motility and functional plasticity of dendritic spines.
- L. de Vivo
- , S. Landi
- & G.M. Ratto
Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex