Spinal cord

  • Article
    | Open Access

    Scoliosis due to trunk muscle paralysis frequently requires surgical treatment in children with spinal cord injury. The authors demonstrate the safety and efficacy of transcutaneous spinal stimulation to enable upright sitting posture in 7/8 children with trunk control impairment in a within-subjects, repeated measures pilot clinical trial.

    • Anastasia Keller
    • , Goutam Singh
    •  & Andrea L. Behrman
  • Article
    | Open Access

    Single-cell profiling has led to the identification of diverse cell types. Here, the authors generate a harmonized cell atlas of the mouse post-natal spinal cord. They also provide spatial analysis of the distribution of the identified cell types and an open-source cell type classifier.

    • Daniel E. Russ
    • , Ryan B. Patterson Cross
    •  & Ariel J. Levine
  • Article
    | Open Access

    The mechanisms stimulating adult neurogenesis are unclear. Here, the authors show the contribution of cholinergic and GABAergic signalling within the locomotor network to spinal cord neurogenesis during homeostasis and regeneration, showing neurogenesis depends on circuit activity in the adult zebrafish.

    • Weipang Chang
    • , Andrea Pedroni
    •  & Konstantinos Ampatzis
  • Article
    | Open Access

    The full heterogeneity and different functional roles of cholinergic neurons in the adult spinal cord remain to be defined. Here the authors develop a targeted single nuclear RNA sequencing approach and use it to identify an array of cholinergic interneurons, as well as visceral and skeletal motor neurons.

    • Mor R. Alkaslasi
    • , Zoe E. Piccus
    •  & Claire E. Le Pichon
  • Article
    | Open Access

    There are few studies of structural changes in ascending and descending sensorimotor pathways after stroke, beyond the corticospinal tract, in the brain. Here the authors identify changes in white matter structure in brainstem and spinal cord following stroke, and show its relationship to motor impairment.

    • Haleh Karbasforoushan
    • , Julien Cohen-Adad
    •  & Julius P. A. Dewald
  • Article
    | Open Access

    Spinal CPGs transmit movement commands through rhythmic synaptic drive onto the spinal premotor network. Here, the authors use paired recordings to demonstrate that spinal neurons have decorrelated synaptic activity suggesting a CPG network with sparse convergent connectivity.

    • Marija Radosevic
    • , Alex Willumsen
    •  & Rune W. Berg
  • Article
    | Open Access

    During evoked swims, zebrafish larvae transition from fast to slow speeds. Here, the authors elucidate the circuit mechanisms in the central pattern generators in the spinal cord and show that genetically labeled V1 spinal interneurons provide in phase inhibition onto fast and slow motor neurons that are involved in the switching behaviour.

    • Yukiko Kimura
    •  & Shin-ichi Higashijima
  • Article
    | Open Access

    Respiratory failure is one of the leading causes of death following spinal cord injury and it is unclear if normal respiratory motor activity can be recovered after chronic injury-induced paralysis. Here, authors show that treatment with chondroitinase ABC induces robust rescue of breathing up to 1.5 years following complete hemidiaphragm paralysis.

    • Philippa M. Warren
    • , Stephanie C. Steiger
    •  & Jerry Silver
  • Article
    | Open Access

    Intra- and interlimb coordination during locomotion is governed by hierarchically organized lumbar spinal networks. Here, the authors show that reversible silencing of spinal L2–L5 interneurons specifically disrupts hindlimb alternation leading to a continuum of walking to hopping.

    • Amanda M. Pocratsky
    • , Darlene A. Burke
    •  & David S. K. Magnuson
  • Article
    | Open Access

    The generation of vasculature in organs is regulated by cross-talk between the developing tissue and specialized endothelial cells. Here, the authors show that vessel growth feeding the zebrafish spinal cord is coordinated by balancing neuron-derived pro-angiogenic ligand Vegfaa and its receptor, sFlt1.

    • Raphael Wild
    • , Alina Klems
    •  & Ferdinand le Noble
  • Article
    | Open Access

    Imaging cellular activity in mouse spinal cord has been historically difficult. Here the authors develop cellular resolution fluorescence imaging approaches in the spinal cord of behaving mice, and report distinct activity patterns of neurons and astrocytes in response to different sensory inputs.

    • Kohei J. Sekiguchi
    • , Pavel Shekhtmeyster
    •  & Axel Nimmerjahn
  • Article
    | Open Access

    Cerebrospinal fluid-contacting (CSF-c) cells line the central canal of the vertebrate spinal cord yet their function remains unknown. Here, Javaland et al. show that CSF-c neurons in the lamprey respond to mechanical stimulation and lowered pH, effects likely mediated by ASIC3-channels.

    • Elham Jalalvand
    • , Brita Robertson
    •  & Sten Grillner
  • Article |

    During vertebrate embryogenesis, migration of neuronal cell bodies and axons occurs simultaneously, but to what degree they influence each other’s development remains unclear. Here the authors find that in the mouse spinal cord commissural axons influence neuronal migration in two different ways.

    • Christophe Laumonnerie
    • , Yong Guang Tong
    •  & Sara I. Wilson
  • Article |

    The spinal V2a interneurons control left–right limb alternation during mouse locomotion, but only at high frequencies. In this study, the authors show that only half of these neurons are active during locomotion, and that they receive increasing synaptic drive to increase their activity as locomotion accelerates.

    • Guisheng Zhong
    • , Kamal Sharma
    •  & Ronald M. Harris-Warrick