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A spinal cord injury consists of damage to the spinal cord that results from external trauma including accidents, falls and sports-related injuries, rather than a degenerative disease. The effects of a spinal cord injury widely vary from no effect, to pain, or to complete loss of spinal cord function.
Zebrafish can regenerate after paralyzing spine injuries and regain locomotor ability, unlike mammals. Here authors show that the neurogenic factor Hb-egf promotes spinal cord regeneration in zebrafish and is regulated by an enhancer that can similarly direct expression in the pro-regenerative setting of neonatal mice.
The cellular responses below the lesion remain unclear after spinal cord injury (SCI). Here, authors show region-heterogeneous responses in the SCI monkey by single-cell transcriptomics analysis and uncover the mechanism of scaffold-based SCI repair.
Efficient delivery of extracellular vesicles to the injured spinal cord, with minimal damage, remains challenging. Here, the authors fabricate a minimally invasive microneedle device, which provides efficient and sustained extracellular vesicle delivery for spinal cord injury treatment.
In a mouse model of spinal cord injury, the developmental stage of transplanted neural progenitor cells is shown to influence anatomical and behavioral outcomes after spinal cord injury
Spiny mice (Acomys cahirinus) are revealed to recover motor co-ordination following complete spinal cord transection, owing to regrowth of axonal motor pathways across the lesion site.
Regenerative neurogenesis after spinal cord injury in zebrafish involves TNF signalling between lesion-activated macrophages and spinal progenitor cells.
