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| Open AccessThe use of solid phase microextraction for metabolomic analysis of non-small cell lung carcinoma cell line (A549) after administration of combretastatin A4
- Karol Jaroch
- , Ezel Boyaci
- & Barbara Bojko
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| Open AccessAtmospheric CO2 captured by biogenic polyamines is transferred as a possible substrate to Rubisco for the carboxylation reaction
- Ko Yasumoto
- , Tsuyoshi Sakata
- & Shugo Watabe
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| Open AccessSmall Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease
- Bo Zhang
- , Joanna M Watt
- & Barry V. L. Potter
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| Open AccessStructure analysis and antiviral activity of CW-33 analogues against Japanese encephalitis virus
- Jin-Cherng Lien
- , Ching-Ying Wang
- & Cheng-Wen Lin
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| Open AccessThe G-quadruplex fluorescent probe 3,6-bis(1-methyl-2-vinyl-pyridinium) carbazole diiodide as a biosensor for human cancers
- Ting-Yuan Tseng
- , Wei-Wen Chen
- & Ta-Chau Chang
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| Open AccessInhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells
- Jin Xu
- , Yun-Fang Jia
- & Chong Hyun Shin
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| Open AccessSynthetic cADPR analogues may form only one of two possible conformational diastereoisomers
- Joanna M. Watt
- , Mark P. Thomas
- & Barry V. L. Potter
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| Open AccessStructural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors
- André da Silva Santiago
- , Rafael M. Couñago
- & Jonathan M. Elkins
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| Open AccessA new ESI-LC/MS approach for comprehensive metabolic profiling of phytocannabinoids in Cannabis
- Paula Berman
- , Kate Futoran
- & David Meiri
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| Open AccessKartogenin inhibits pain behavior, chondrocyte inflammation, and attenuates osteoarthritis progression in mice through induction of IL-10
- Ji Ye Kwon
- , Seung Hoon Lee
- & Mi-La Cho
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| Open AccessA novel molecular rotor facilitates detection of p53-DNA interactions using the Fluorescent Intercalator Displacement Assay
- Walter L. Goh
- , Min Yen Lee
- & Yin Nah Teo
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| Open AccessA Mixture of Atropisomers Enhances Neutral Lipid Degradation in Mammalian Cells with Autophagy Induction
- Keisuke Kobayashi
- , Satoshi Ohte
- & Hiroshi Tomoda
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| Open AccessA Novel Compound, “FA-1” Isolated from Prunus mume, Protects Human Bronchial Epithelial Cells and Keratinocytes from Cigarette Smoke Extract-Induced Damage
- Andrew J. Jang
- , Ji-Hyeok Lee
- & Toru Nyunoya
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| Open AccessExposure to Polycyclic Aromatic Hydrocarbons Leads to Non-monotonic Modulation of DNA and RNA (hydroxy)methylation in a Rat Model
- Radu-Corneliu Duca
- , Nathalie Grova
- & Lode Godderis
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| Open AccessA selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation
- Alina Castell
- , Qinzi Yan
- & Lars-Gunnar Larsson
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| Open AccessArabidopsis mutants impaired in glutathione biosynthesis exhibit higher sensitivity towards the glucosinolate hydrolysis product allyl-isothiocyanate
- János Urbancsok
- , Atle M. Bones
- & Ralph Kissen
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| Open AccessA widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase
- Natalia J. Martinez
- , Rosita R. Asawa
- & Mark J. Henderson
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| Open AccessAn Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors
- Matthew Bratkowski
- , Xin Yang
- & Xin Liu
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| Open AccessSynthesis, fungicidal activity, structure-activity relationships (SARs) and density functional theory (DFT) studies of novel strobilurin analogues containing arylpyrazole rings
- Yuanyuan Liu
- , Kunzhi Lv
- & Jinyuan Xu
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| Open AccessA Comparison of the Antibacterial and Antifungal Activities of Thiosulfinate Analogues of Allicin
- Roman Leontiev
- , Nils Hohaus
- & Alan J. Slusarenko
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| Open AccessSauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network
- Hee-Sung Chae
- , Byoung Hoon You
- & Young-Won Chin
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| Open AccessMechanism of action of the third generation benzopyrans and evaluation of their broad anti-cancer activity in vitro and in vivo
- Alexander J. Stevenson
- , Eleanor I. Ager
- & Brian G. Gabrielli
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| Open AccessSize Exclusion Chromatography Method for Purification of Nicotinamide Mononucleotide (NMN) from Bacterial Cells
- George Cătălin Marinescu
- , Roua-Gabriela Popescu
- & Anca Dinischiotu
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| Open AccessHigh-affinity ligands of the colchicine domain in tubulin based on a structure-guided design
- Oskía Bueno
- , Juan Estévez Gallego
- & Eva-María Priego
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| Open AccessHSP27 inhibitor attenuates radiation-induced pulmonary inflammation
- Jee-Youn Kim
- , Yong-Min An
- & Jaeho Cho
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| Open AccessIdentification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance
- Safia Manzoor
- , Aishah Bilal
- & Amir Faisal
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| Open AccessSmall molecule anionophores promote transmembrane anion permeation matching CFTR activity
- Elsa Hernando
- , Valeria Capurro
- & Roberto Quesada
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| Open AccessEthyl-substitutive Thioflavin T as a highly-specific fluorescence probe for detecting G-quadruplex structure
- Ai-jiao Guan
- , Xiu-Feng Zhang
- & Ya-Lin Tang
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| Open Access2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors
- Yves Nkizinkiko
- , Jenny Desantis
- & Lari Lehtiö
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| Open AccessModulation of oncogenic miRNA biogenesis using functionalized polyamines
- Cathy Staedel
- , Thi Phuong Anh Tran
- & Maria Duca
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| Open AccessNew 5-Aryl-Substituted 2-Aminobenzamide-Type HDAC Inhibitors with a Diketopiperazine Group and Their Ameliorating Effects on Ischemia-Induced Neuronal Cell Death
- Yoshiyuki Hirata
- , Tsutomu Sasaki
- & Shinichi Uesato
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| Open AccessCardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling
- Raymond W. Wong
- , Clifford A. Lingwood
- & Alan Cochrane
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| Open AccessCorrelation of Gli1 and HER2 expression in gastric cancer: Identification of novel target
- Xinyu Shao
- , Xiaoyi Kuai
- & Chunli Zhou
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| Open AccessPiperonylic acid stimulates keratinocyte growth and survival by activating epidermal growth factor receptor (EGFR)
- Dohyun Lee
- , Jinsun Lim
- & Kyong-Tai Kim
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| Open AccessDevelopment of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells
- Christian Lis
- , Stefan Rubner
- & Thorsten Berg
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| Open AccessProtein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease
- Diane Beylkin
- , Gyanendra Kumar
- & Thomas R. Webb
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| Open AccessIdentification of insulin-sensitizing molecules acting by disrupting the interaction between the Insulin Receptor and Grb14
- Anaïs Gondoin
- , Cornelia Hampe
- & Anne-Françoise Burnol
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| Open AccessThe Association between Galectin-3 and hs-CRP and the Clinical Outcome after Non-ST-Elevation Myocardial Infarction with Preexisting Atrial Fibrillation
- Milan Pavlović
- , Svetlana Apostolović
- & Valentina N. Nikolic
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| Open AccessCytotoxicity of Aconitum alkaloid and its interaction with calf thymus DNA by multi-spectroscopic techniques
- Fei Liu
- , Xiaoxin Tan
- & Weijun Kang
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| Open AccessStabilization of mouse haploid embryonic stem cells with combined kinase and signal modulation
- Haisen Li
- , Ao Guo
- & Li Shen
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| Open AccessPhyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities
- Heng-Gang Yang
- , Huan Zhao
- & Hao Gao
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| Open AccessHigh-Affinity Functional Fluorescent Ligands for Human β-Adrenoceptors
- Gyuzel Y. Mitronova
- , Gražvydas Lukinavičius
- & Stefan W. Hell
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| Open AccessAn invertebrate infection model for evaluating anti-fungal agents against dermatophytosis
- Masaki Ishii
- , Yasuhiko Matsumoto
- & Kazuhisa Sekimizu
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| Open AccessPolyphenols journey through blood-brain barrier towards neuronal protection
- I. Figueira
- , G. Garcia
- & C. N. Santos
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| Open AccessIdentification and characterization of the novel reversible and selective cathepsin X inhibitors
- Urša Pečar Fonović
- , Ana Mitrović
- & Janko Kos
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| Open AccessThiosemicarbazone scaffold for the design of antifungal and antiaflatoxigenic agents: evaluation of ligands and related copper complexes
- Dominga Rogolino
- , Anna Gatti
- & Claudia Zani
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| Open AccessSynthesis, high-throughput screening and pharmacological characterization of β–lactam derivatives as TRPM8 antagonists
- Roberto de la Torre-Martínez
- , M. Angeles Bonache
- & Rosario González-Muñiz
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| Open AccessReversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy
- Nikolaos D. Georgakopoulos
- , Michele Frison
- & Michelangelo Campanella
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| Open AccessPutrescine independent wound response phenotype is produced by ODC-like RNAi in planarians
- Lucia Cassella
- , Alessandra Salvetti
- & Leonardo Rossi