siRNAs articles within Nature

Featured

  • Article |

    The active-state structure of human DICER bound to pre-miRNA reveals the structural basis for the specificity of DICER in how it selects substrates in a sequence dependent manner, and sheds light on DICER-related diseases.

    • Young-Yoon Lee
    • , Hansol Lee
    •  & Soung-Hun Roh

  • Article |

    Massively parallel assays reveal a highly conserved sequence motif termed the GYM motif, which potentiates RNA interference by directing Dicer-mediated small RNA processing.

    • Young-Yoon Lee
    • , Haedong Kim
    •  & V. Narry Kim

  • Article |

    In Caenorhabditis elegans, the ribonucleotidyltransferase RDE-3 adds alternating uridine and guanosine ribonucleotides to the 3′ termini of RNAs, a key step in RNA interference and thus epigenetic inheritance in the C. elegans germline.

    • Aditi Shukla
    • , Jenny Yan
    •  & Scott Kennedy

  • Article |

    ZNFX-1 and WAGO-4 localize to germ granules in early Caenorhabditis elegans embryogenesis and later separate to form independent liquid-like droplets, and the temporal and spatial ordering of these droplets may help cells to organize complex RNA processing pathways.

    • Gang Wan
    • , Brandon D. Fields
    •  & Scott Kennedy

  • Letter |

    The main reason why tumours are not controlled by the immune system is that they do not express potent tumour rejection antigens. Tumour vaccination aims to provoke a response to any antigens that are expressed. Here, a new approach is described: nonsense-mediated messenger RNA decay in tumour cells is inhibited, leading to the expression of new antigens and to significant inhibition of tumour growth in mice.

    • Fernando Pastor
    • , Despina Kolonias
    •  & Eli Gilboa

  • Technology Feature |

    The scientific community now seems convinced that small RNAs will become therapies, if new tools can help these large molecules to make it safely into cells. Monya Baker reports.

    • Monya Baker

  • Letter |

    It has previously been shown in mice and non-human primates that systemically delivered short RNA molecules can inhibit gene expression. Here it is shown that a short interfering RNA (siRNA) can be systemically delivered, using nanoparticles, to a solid tumour in humans. The siRNA mediates cleavage of its target mRNA, thereby also reducing levels of the encoded protein. This proof-of-principle study confirms the potential of this technology for treating human disease.

    • Mark E. Davis
    • , Jonathan E. Zuckerman
    •  & Antoni Ribas

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