Single-strand DNA breaks articles within Nature

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• Article | 28 September 2022

  A mechanism for oxidative damage repair at gene regulatory elements

  The nuclear mitotic apparatus protein NuMA helps to protect genes from oxidative damage by occupying regions around transcription start sites, binding DNA repair factors and promoting transcription following damage.

  • Swagat Ray
  • , Arwa A. Abugable
  •  & Sherif F. El-Khamisy

• Article | 25 March 2021

  Neuronal enhancers are hotspots for DNA single-strand break repair

  DNA single-strand breaks in neurons accumulate at high levelsin functional enhancers.

  • Wei Wu
  • , Sarah E. Hill
  •  & André Nussenzweig