Signalling gradients articles within Nature Communications

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  • Article
    | Open Access

    The human brain integrates inputs across multiple sensory streams into a unified percept. Here Parise and Ernst present a model that assesses the correlation, lag and synchrony of multisensory stimuli, and predicts psychophysical performance on multisensory temporal and spatial tasks.

    • Cesare V. Parise
    •  & Marc O. Ernst

  • Article
    | Open Access

    Gradients of the secreted morphogen Sonic Hedgehog (Shh) pattern the neural tube in vertebrates. Cohen et al.quantify Shh signalling in developing mice, and by constructing a computational model of the process, identify mechanisms by which the dynamics of Shh signalling are regulated.

    • Michael Cohen
    • , Anna Kicheva
    •  & James Briscoe

  • Article
    | Open Access

    Epileptic seizures generate aberrant neurogenesis in the adult mouse hippocampal region but how animals cope with abnormal neurogenesis remains unknown. Here the authors show that microglia are activated through TLR9 signaling and that this leads to sustained expression of TNF-α which attenuates induced aberrant neurogenesis.

    • Taito Matsuda
    • , Naoya Murao
    •  & Kinichi Nakashima

  • Article |

    The auditory systems of animals that perceive sounds in air are organized so that mechanosensory hair cells located at different positions respond to specific frequencies. Here, Mann et al. find that a gradient of Bmp7 controls the determination of frequency-specific hair cell characteristics in the chick auditory system.

    • Zoë F. Mann
    • , Benjamin R. Thiede
    •  & Matthew W. Kelley

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