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Article
| Open Access
Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme
Mesenchymal lineages play critical roles during development, though these cells are frequently overlooked in directed differentiation models. Here they derive lung-specific mesenchyme from mouse iPSCs and generate organoids consisting of both mesenchymal and epithelial progenitors, observing functional epithelial-mesenchymal crosstalk.
- Andrea B. Alber
- , Hector A. Marquez
- & Darrell N. Kotton
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Comment
| Open AccessEmerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients
There is an urgent need for drugs, therapies and vaccines to be available to protect the human population against COVID-19. One of the first approaches taken in the COVID-19 global response was to consider repurposing licensed drugs. This commentary highlights an extraordinary international collaborative effort of independent researchers who have recently all come to the same conclusion—that chloroquine or hydroxchloroquine are unlikely to provide clinical benefit against COVID-19.
- S. G. P. Funnell
- , W. E. Dowling
- & C. M. Coleman
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Article
| Open Access
Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth
The respiratory system is transformed in terms of functional change at birth to adapt to breathing air. Here, the authors examine the molecular changes behind the first breath in the mouse by Drop-seq based RNA sequencing, identifying activation of the unfolded protein response as a perinatal adaptation of the lung.
- Minzhe Guo
- , Yina Du
- & Yan Xu
Human apical-out nasal organoids reveal an essential role of matrix metalloproteinases in airway epithelial differentiation