Reproductive signs and symptoms articles within Nature Communications

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  • Article
    | Open Access

    Gaining mechanistic insight into the microbiological and immunological factors that are associated with spontaneous preterm birth is important for the development of prevention strategies. Here authors show that the complement system in conjunction with specific vaginal microbial and associated immunological changes are contributing to this condition.

    • Denise Chan
    • , Phillip R. Bennett
    •  & Lynne Sykes

  • Article
    | Open Access

    As pregnant women are considered vulnerable to SARSCoV-2 infection, it is important to investigate the actual risks involved. The authors show here that, while a T cell-dominant inflammatory response is observed at the maternal-foetal interface, the virus remains undetectable in the placenta but triggers specific immune responses in the neonatal (umbilical cord blood) circulation.

    • Valeria Garcia-Flores
    • , Roberto Romero
    •  & Nardhy Gomez-Lopez

  • Article
    | Open Access

    Anterior vaginal prolapse (AVP), the most common form of pelvic organ prolapse, has deleterious effects on women’s health. Here the authors employ single-cell RNA-seq to construct a transcriptomic atlas of vaginal wall cells from AVP patients, and find that extracellular matrix dysregulation and immune reaction are associated with AVP.

    • Yaqian Li
    • , Qing-Yang Zhang
    •  & Lan Zhu

  • Article
    | Open Access

    Gestational duration depends on both maternal and fetal genetic influences. Here, the authors perform a fetal genome-wide association meta-analysis and find that a locus on 2q13 is associated with pregnancy duration and further show that the lead SNP rs7594852 changes the binding properties of transcriptional repressor HIC1.

    • Xueping Liu
    • , Dorte Helenius
    •  & Bjarke Feenstra

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