Featured
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Article |
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
The tumour microenvironment is low in glucose and high in the alternative metabolite lactate, which regulatory T cells are shown here to use, maintaining their ability to suppress effector immune cells.
- McLane J. Watson
- , Paolo D. A. Vignali
- & Greg M. Delgoffe
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Letter |
Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery
In a mouse model of ischaemic stroke, regulatory T cells infiltrate the injured brain in response to the chemokines CCL1 and CCL20 and suppress excessive astrogliosis via the production of amphiregulin.
- Minako Ito
- , Kyoko Komai
- & Akihiko Yoshimura
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Article |
Immune homeostasis enforced by co-localized effector and regulatory T cells
Autoantigen-presenting dendritic cells are shown to interact with both effector and regulatory T cells, and effector-produced IL-2 activates the transcription factor STAT5 in regulatory T cells, which in turn upregulates suppressive molecules and prevents autoimmunity.
- Zhiduo Liu
- , Michael Y. Gerner
- & Ronald N. Germain
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Letter |
Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis
Neuropilin-1 (Nrp1) on regulatory T (Treg) cells is shown to interact with semaphorin-4a (Sema4a) to promote a program of Treg-cell stability and survival, in part through PTEN-mediated modulation of Akt signalling; Nrp1-deficient Treg cells can maintain immune homeostasis but fail to suppress in inflammatory sites, such as tumours, providing an attractive immunotherapeutic target for the treatment of cancers.
- Greg M. Delgoffe
- , Seng-Ryong Woo
- & Dario A. A. Vignali
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Letter |
mTORC1 couples immune signals and metabolic programming to establish Treg-cell function
Here, mTORC1-dependent lipogenic programming is shown to be important for regulatory T-cell function, in part through the upregulation of the effector molecules CTLA4 and ICOS.
- Hu Zeng
- , Kai Yang
- & Hongbo Chi
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Letter |
BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis
Diverse autoimmune and allergic diseases are associated with polymorphisms in a locus encoding the transcription factor BACH2; here, BACH2 is shown to be a broad regulator of immune activation that stabilizes the differentiation of Treg cells by repressing commitment of CD4+ T cells to alternate cell fates.
- Rahul Roychoudhuri
- , Kiyoshi Hirahara
- & Nicholas P. Restifo
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Article |
Novel Foxo1-dependent transcriptional programs control Treg cell function
The results of a series of genetic experiments indicate that Foxo1 has a pivotal, Foxp3-independent role controlling regulatory T-cell function.
- Weiming Ouyang
- , Will Liao
- & Ming O. Li
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Letter |
Response to self antigen imprints regulatory memory in tissues
Thymus-derived regulatory T cells are activated by recognition of peripheral self antigen, persist in the target tissue on cessation of antigen exposure, and respond to re-exposure to self antigen with enhanced functional activity.
- Michael D. Rosenblum
- , Iris K. Gratz
- & Abul K. Abbas
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News |
How microbes train our immune system
Gut bacteria coax T cells to see them as friends.
- Alla Katsnelson
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Letter |
In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche
- Joji Fujisaki
- , Juwell Wu
- & Charles P. Lin
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Letter |
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
Immune homeostasis relies on tight control over the size of a population of regulatory T cells (Treg) that can suppress over-exuberant immune responses. Cells commit to the Treg lineage by upregulating the transcription factor Foxp3. Conserved non-coding DNA sequence elements at the Foxp3 locus are now shown to control the composition, size and maintenance of the Treg cell population.
- Ye Zheng
- , Steven Josefowicz
- & Alexander Y. Rudensky