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| Open AccessNeurofibromin 1 controls metabolic balance and Notch-dependent quiescence of murine juvenile myogenic progenitors
The establishment of the postnatal skeletal muscle stem cell pool is not well understood. Here the authors show a requirement for Nf1 to coordinate muscle fiber growth and stem cell quiescence induction, and to prevent detrimental metabolic reprogramming with life-long consequences.
- Xiaoyan Wei
- , Angelos Rigopoulos
- & Sigmar Stricker
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| Open AccessATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression
Muscle regeneration relies on activation and expansion of skeletal muscle stem cells. Here, authors show that ATF3 induction prevents precocious activation of skeletal muscle stem cells by binding and promoting the transcription of Histone2B.
- Suyang Zhang
- , Feng Yang
- & Huating Wang
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Article
| Open AccessCPEB1 directs muscle stem cell activation by reprogramming the translational landscape
Skeletal muscle stem cells are actively maintained in quiescence, but can activate quickly upon extrinsic stimulation. Here the authors show that CPEB1 promotes muscle stem cell activation by reprogramming the translational landscape.
- Wenshu Zeng
- , Lu Yue
- & Tom H. Cheung
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| Open AccessEnhanced germline stem cell longevity in Drosophila diapause
Drosophila enter adult reproductive diapause in low temperatures and short day, halting ovarian development yet preserving fertility. Here the authors show that ovarian arrest in diapause is distinct from other stress responses and that despite DNA damage and decreased division, germline stem cells recover.
- Sreesankar Easwaran
- , Matthew Van Ligten
- & Denise J. Montell
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| Open AccessCell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module
Adult neural stem cells are derived from an embryonic population of slowcycling progenitor cells, though how reduced cycling speed leads to establishment of the adult population has remained elusive. Here they show that non-oscillatory Notch-Hey signaling induced by slow-cycling contributes to long term maintenance of neural stem cells.
- Yujin Harada
- , Mayumi Yamada
- & Yukiko Gotoh
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| Open AccessLRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells
How neural stem cells can transition between states of proliferation and quiescence is unclear. Here, the authors identify Lrig1 as a specific marker for the primed quiescent state and demonstrate that Lrig1 maintains cells in a quiescent state via modulation of the EGFR pathway.
- María Ángeles Marqués-Torrejón
- , Charles A. C. Williams
- & Steven M. Pollard
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| Open AccessIndispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells
Long term haematopoitic stem cells (LT-HSCs) are in a quiescent state during homeostasis, which is critical for their maintenance. Here, the authors show that Gal-3 expression in LT-HSCs is induced in response to Tie2 and Mpl and is both necessary and sufficient for LT-HSC quiescence through regulation of p21.
- Weizhen Jia
- , Lingyu Kong
- & Nobuyuki Takakura
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| Open AccessEnhanced lysosomal degradation maintains the quiescent state of neural stem cells
It remains unclear why quiescent neural stem cells (qNSCs) in the subventricular zone of the mouse brain have enlarged lysosomes. Here, authors demonstrate that qNSCs exhibit higher lysosomal activity and degrade activated EGF receptor by endolysosomal degradation more rapidly than proliferating NSCs, which prevents the NSC exit from quiescence.
- Taeko Kobayashi
- , Wenhui Piao
- & Ryoichiro Kageyama
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Article
| Open AccessAWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis
Regeneration after injury in the Drosophila intestine involves early activation of intestinal stem cells (ISCs) and subsequent return to quiescence. Here the authors show that return to quiescence by ISCs involves BMP Type I receptor Tkv protein stabilization along with AWD mediated internalization into endocytic vesicles.
- Xiaoyu Tracy Cai
- , Hongjie Li
- & Heinrich Jasper
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| Open AccessInduction of muscle stem cell quiescence by the secreted niche factor Oncostatin M
The factors that mediate quiescence of muscle stem cells are unknown. The authors show that Oncostatin M is produced by skeletal muscle, suppresses stem cell proliferation, and that its deletion in muscle results in stem cell depletion and impaired muscle regeneration following injury in mice.
- Srinath C. Sampath
- , Srihari C. Sampath
- & Helen M. Blau
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| Open AccessNon-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
Following demyelination injury, neural stem cells (NSCs) in the subventricular zone switch to an activated state. Here, the authors show that a transient shift from non-canonical to canonical Wnt signaling is necessary for activation of quiescent NSCs to achieve tissue homeostasis and brain repair.
- Manideep Chavali
- , Michael Klingener
- & Adan Aguirre
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| Open AccessSignalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis
Changes in global histone trimethylation have been linked to embryonic but not adult stem cell plasticity. Here, Lee et al. find H3 K4/K9/K27me3 levels actively reduced in adult mouse skin and hair follicle stem cells during quiescence (catagen) and link this to active bone morphogen protein signalling.
- Jayhun Lee
- , Sangjo Kang
- & Tudorita Tumbar
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| Open AccessThe Hippo signalling pathway maintains quiescence in Drosophila neural stem cells
Drosophila neural stem cells (NSCs) are quiescent at early larval stages but how this is regulated is unclear. Here, Ding et al. show that quiescence of NSCs is mediated by cell-contact inhibition via the Hippo pathway transmembrane proteins Crumbs and Echinoid, which in turn are regulated by nutrient levels.
- Rouven Ding
- , Kevin Weynans
- & Christian Berger
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| Open AccessHaematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability
Hematopoietic stem and progenitor cell (HSPCs) proliferation is controlled by signals from the niche. Here, Leivaet al. show in vivoin mice that deletion of E-selectin ligand 1 causes quiescence of HSPCs and a reduction in niche size, which is mediated by changes of TGFß levels in the bone marrow.
- Magdalena Leiva
- , Juan A. Quintana
- & Andrés Hidalgo
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| Open AccessIntegrin-linked kinase regulates the niche of quiescent epidermal stem cells
Integrin-linked kinase (ILK) is known to modulate the extracellular matrix and hair follicle morphogenesis. Here, Morgner et al.show that lack of ILK causes an aberrant ratio of basement membrane laminins, activating stem cells and predisposing skin to carcinogenesis.
- Jessica Morgner
- , Sushmita Ghatak
- & Sara A. Wickström
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NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes
Tumour cells disseminated from the primary tumour can remain dormant for years before initiating metastases. Here Sosa et al.show that the orphan nuclear receptor NR2F1 can be induced by bone marrow cues and by epigenetic drugs to promote quiescence and tumour cell dormancy in several cancer types.
- Maria Soledad Sosa
- , Falguni Parikh
- & Julio A. Aguirre-Ghiso
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| Open AccessROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells
The quiescent centre controls stem cell differentiation at the root apical meristem. Here Zhang et al. propose that ROW1 maintains meristem cell identity by repressing expression of the WOX5transcription factor in the proximal meristem zone, thus confining its activity to the quiescent centre.
- Yuzhou Zhang
- , Yue Jiao
- & Yu-Xian Zhu
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miR-195/497 induce postnatal quiescence of skeletal muscle stem cells
Skeletal muscle stem cells are in a state of cell cycle arrest in adult skeletal muscles and are stimulated to proliferate and differentiate in response to injury or pathology. Here the authors identify two microRNAs, miR-195 and miR-497, which induce cell cycle arrest in the stem cells and suppress myogenesis.
- Takahiko Sato
- , Takuya Yamamoto
- & Atsuko Sehara-Fujisawa
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G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes
The resting zone of the growth plate of mammalian long bones contains stem-like chondrocytes. Here, the authors show that G-protein stimulatory alpha subunit, Gsα, and the Gq/11α G-proteins together protect stem-like chondrocytes from apoptosis and preserve chondrocyte quiescence in mouse growth plates.
- Andrei S. Chagin
- , Karuna K. Vuppalapati
- & Henry M. Kronenberg
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Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity
Stem cells hold great potential for therapeutic use but their supply is limited. Latilet al.isolate muscle stem cells from human and mouse cadavers after 17 and 14 days, respectively, and show that when transplanted into mice the cells can regenerate tissues.
- Mathilde Latil
- , Pierre Rocheteau
- & Fabrice Chrétien