Quiescence

  • Article
    | Open Access

    How neural stem cells can transition between states of proliferation and quiescence is unclear. Here, the authors identify Lrig1 as a specific marker for the primed quiescent state and demonstrate that Lrig1 maintains cells in a quiescent state via modulation of the EGFR pathway.

    • María Ángeles Marqués-Torrejón
    • , Charles A. C. Williams
    •  & Steven M. Pollard
  • Article
    | Open Access

    Long term haematopoitic stem cells (LT-HSCs) are in a quiescent state during homeostasis, which is critical for their maintenance. Here, the authors show that Gal-3 expression in LT-HSCs is induced in response to Tie2 and Mpl and is both necessary and sufficient for LT-HSC quiescence through regulation of p21.

    • Weizhen Jia
    • , Lingyu Kong
    •  & Nobuyuki Takakura
  • Article
    | Open Access

    It remains unclear why quiescent neural stem cells (qNSCs) in the subventricular zone of the mouse brain have enlarged lysosomes. Here, authors demonstrate that qNSCs exhibit higher lysosomal activity and degrade activated EGF receptor by endolysosomal degradation more rapidly than proliferating NSCs, which prevents the NSC exit from quiescence.

    • Taeko Kobayashi
    • , Wenhui Piao
    •  & Ryoichiro Kageyama
  • Article
    | Open Access

    Regeneration after injury in the Drosophila intestine involves early activation of intestinal stem cells (ISCs) and subsequent return to quiescence. Here the authors show that return to quiescence by ISCs involves BMP Type I receptor Tkv protein stabilization along with AWD mediated internalization into endocytic vesicles.

    • Xiaoyu Tracy Cai
    • , Hongjie Li
    •  & Heinrich Jasper
  • Article
    | Open Access

    The factors that mediate quiescence of muscle stem cells are unknown. The authors show that Oncostatin M is produced by skeletal muscle, suppresses stem cell proliferation, and that its deletion in muscle results in stem cell depletion and impaired muscle regeneration following injury in mice.

    • Srinath C. Sampath
    • , Srihari C. Sampath
    •  & Helen M. Blau
  • Article
    | Open Access

    Following demyelination injury, neural stem cells (NSCs) in the subventricular zone switch to an activated state. Here, the authors show that a transient shift from non-canonical to canonical Wnt signaling is necessary for activation of quiescent NSCs to achieve tissue homeostasis and brain repair.

    • Manideep Chavali
    • , Michael Klingener
    •  & Adan Aguirre
  • Article
    | Open Access

    Changes in global histone trimethylation have been linked to embryonic but not adult stem cell plasticity. Here, Lee et al. find H3 K4/K9/K27me3 levels actively reduced in adult mouse skin and hair follicle stem cells during quiescence (catagen) and link this to active bone morphogen protein signalling.

    • Jayhun Lee
    • , Sangjo Kang
    •  & Tudorita Tumbar
  • Article
    | Open Access

    Drosophila neural stem cells (NSCs) are quiescent at early larval stages but how this is regulated is unclear. Here, Ding et al. show that quiescence of NSCs is mediated by cell-contact inhibition via the Hippo pathway transmembrane proteins Crumbs and Echinoid, which in turn are regulated by nutrient levels.

    • Rouven Ding
    • , Kevin Weynans
    •  & Christian Berger
  • Article
    | Open Access

    Integrin-linked kinase (ILK) is known to modulate the extracellular matrix and hair follicle morphogenesis. Here, Morgner et al.show that lack of ILK causes an aberrant ratio of basement membrane laminins, activating stem cells and predisposing skin to carcinogenesis.

    • Jessica Morgner
    • , Sushmita Ghatak
    •  & Sara A. Wickström
  • Article |

    Tumour cells disseminated from the primary tumour can remain dormant for years before initiating metastases. Here Sosa et al.show that the orphan nuclear receptor NR2F1 can be induced by bone marrow cues and by epigenetic drugs to promote quiescence and tumour cell dormancy in several cancer types.

    • Maria Soledad Sosa
    • , Falguni Parikh
    •  & Julio A. Aguirre-Ghiso
  • Article
    | Open Access

    The quiescent centre controls stem cell differentiation at the root apical meristem. Here Zhang et al. propose that ROW1 maintains meristem cell identity by repressing expression of the WOX5transcription factor in the proximal meristem zone, thus confining its activity to the quiescent centre.

    • Yuzhou Zhang
    • , Yue Jiao
    •  & Yu-Xian Zhu
  • Article |

    Skeletal muscle stem cells are in a state of cell cycle arrest in adult skeletal muscles and are stimulated to proliferate and differentiate in response to injury or pathology. Here the authors identify two microRNAs, miR-195 and miR-497, which induce cell cycle arrest in the stem cells and suppress myogenesis.

    • Takahiko Sato
    • , Takuya Yamamoto
    •  & Atsuko Sehara-Fujisawa
  • Article |

    The resting zone of the growth plate of mammalian long bones contains stem-like chondrocytes. Here, the authors show that G-protein stimulatory alpha subunit, Gsα, and the Gq/11α G-proteins together protect stem-like chondrocytes from apoptosis and preserve chondrocyte quiescence in mouse growth plates.

    • Andrei S. Chagin
    • , Karuna K. Vuppalapati
    •  & Henry M. Kronenberg