Psoriasis articles from across Nature Portfolio

Psoriasis is an autoimmune disease in which the skin becomes inflamed, producing red, flaky areas. It affects 1-2% of the population and is thought to be caused by misguided T cell attacks on the skin.

Latest Research and Reviews

Research | 24 February 2023

Newly revealed variants of SERPINA3 in generalized pustular psoriasis attenuate inhibition of ACT on cathepsin G
- Yaqin Liu
- , Hongmei Li
- & Weihui Zhou
Journal of Human Genetics, 1-7
Research
07 December 2022 | Open Access

CD1a promotes systemic manifestations of skin inflammation

Skin inflammation is often accompanied by systemic disease, yet the pathways that regulate this escalation are little known. Here authors show that transgenic expression of human CD1a in mice leads to the escalation of experimental skin inflammation and systemic inflammatory disease, and the generalized symptoms could be alleviated by blocking antibodies developed against CD1a.
- Clare S. Hardman
- , Yi-Ling Chen
- & Graham S. Ogg
Nature Communications 13, 7535
Research
28 November 2022 | Open Access

The causal relationship between psoriasis, psoriatic arthritis, and inflammatory bowel diseases
- Yang Sun
- , Yue Li
- & Jiting Zhang
Scientific Reports 12, 20526
Research
25 November 2022 | Open Access

Mesenchymal stem/stromal cells primed by inflammatory cytokines alleviate psoriasis-like inflammation via the TSG-6-neutrophil axis
- Yayun Ding
- , Pixia Gong
- & Yufang Shi
Cell Death & Disease 13, 996
Research
21 October 2022 | Open Access

CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology

Draber and colleagues show that the tetra-transmembrane protein CMTM4 is a subunit of the IL-17 receptor.
- Daniela Knizkova
- , Michaela Pribikova
- & Peter Draber
Nature Immunology 23, 1644-1652
Research
05 September 2022 | Open Access

Real-world effectiveness of anti-interleukin-23 antibodies in chronic plaque-type psoriasis of patients from the Austrian Psoriasis Registry (PsoRA)
- T. Graier
- , W. Weger
- & Peter Wolf
Scientific Reports 12, 15078

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News and Comment

Research Highlights | 02 August 2022

A protective role for epidermal S100A9 in PsA

A new study uncovers a protective role for epidermal S100A9 in psoriasis and psoriatic arthritis, and highlights this alarmin as a potential biomarker of disease progression.
- Jessica McHugh
Nature Reviews Rheumatology 18, 495
News & Views | 11 October 2021

Does psoriasis treatment affect PsA development?

The results of several retrospective studies have reported that systemic treatment in patients with psoriasis reduces the risk of incident psoriatic arthritis (PsA). Although encouraging from a prevention perspective, such studies are limited in their ability to provide a conclusive understanding of PsA risk, preventing a clear picture from emerging.
- Joseph F. Merola
- & Alexis Ogdie
Nature Reviews Rheumatology 17, 708-709
News & Views | 07 May 2018

Targeting metabolism to treat psoriasis

A crucial role for glucose metabolism has been identified in wound repair and in the pathogenesis of chronic inflammatory skin diseases, indicating that targeting metabolism is an approach for treating psoriasis.
- Paul Hiebert
- & Sabine Werner
Nature Medicine 24, 537-539
Research Highlights | 03 May 2018

Itaconate charges down inflammation

The metabolite itaconate induces electrophilic stress that induces an antioxidant response and regulates secondary TLR transcriptional responses and IL-17-driven pathology.
- Yvonne Bordon
Nature Reviews Immunology 18, 360-361
Research Highlights | 16 April 2018

Old drug, new trick

The immunomodulatory drug dimethyl fumarate blocks GAPDH and aerobic glycolysis in activated immune cells.
- Yvonne Bordon
Nature Reviews Immunology 18, 295
News | 11 September 2017

Go-ahead for first anti-IL-23 mAb to treat psoriasis

Nature Biotechnology 35, 806

All News & Comment

Psoriasis articles from across Nature Portfolio

Latest Research and Reviews

Newly revealed variants of SERPINA3 in generalized pustular psoriasis attenuate inhibition of ACT on cathepsin G

CD1a promotes systemic manifestations of skin inflammation

The causal relationship between psoriasis, psoriatic arthritis, and inflammatory bowel diseases

Mesenchymal stem/stromal cells primed by inflammatory cytokines alleviate psoriasis-like inflammation via the TSG-6-neutrophil axis

CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology

Real-world effectiveness of anti-interleukin-23 antibodies in chronic plaque-type psoriasis of patients from the Austrian Psoriasis Registry (PsoRA)

News and Comment

A protective role for epidermal S100A9 in PsA

Does psoriasis treatment affect PsA development?

Targeting metabolism to treat psoriasis

Itaconate charges down inflammation

Old drug, new trick

Go-ahead for first anti-IL-23 mAb to treat psoriasis

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