Prenylation articles within Nature Communications

Featured

• Article
  04 September 2019 | Open Access

  Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

  Macrophage specific deletion of GGTase-I, a prenylation enzyme, in mice induces inflammatory response and rheumatoid arthritis. Here the authors show that GGTase-I deficiency and the resulting reduction of RAC1 prenylation increase RAC1 interaction with the adaptor protein IQGAP1, leading to GTP-loading of RAC1 and enhanced proinflammatory cytokine production.

  • Murali K. Akula
  • , Mohamed X. Ibrahim
  •  & Martin O. Bergo

• Article
  22 March 2019 | Open Access

  Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

  SREBP transcription factors activate lipid synthesis and generate raw materials to lipidate various proteins. Here, the authors show that a stiff cellular environment causes RhoA lipidation and acto-myosin contraction, which inhibits SREBP1 and connects the extracellular matrix to lipid metabolism.

  • Rebecca Bertolio
  • , Francesco Napoletano
  •  & Giannino Del Sal