Podocytes

Podocytes are highly specialised, terminally differentiated cells that are located in the Bowman's capsule of the kidney. These cells have interdigitated foot processes that are bridged by a membrane called the slit diaphragm, and have a role in the selective permeability of the glomerular filtration barrier.

Latest Research and Reviews

  • Reviews |

    Technological advances continue to expand the use of proteomics in medicine. In this Review, the authors discuss proteomics research findings in nephrology and the potential, as well as the limitations, of using proteomics techniques to uncover disease mechanisms and develop new therapeutic strategies.

    • Markus M. Rinschen
    •  & Julio Saez-Rodriguez
  • Reviews |

    Nuclear receptors have important roles in normal physiological functions and in the pathophysiology of various diseases. Here, the authors focus on the roles of nuclear receptors in podocyte biology and non-diabetic glomerular disease as well as their potential as therapeutic targets.

    • Shipra Agrawal
    • , John C. He
    •  & Pierre-Louis Tharaux
  • Reviews |

    The glomerular basement membrane (GBM) is essential for kidney filtration. This Review describes how studies of GBM composition and structure have provided insights into GBM assembly, its developmental transitions and its role in glomerular filtration. The authors also discuss GBM-associated diseases and current and potential future treatments for these disorders.

    • Richard W. Naylor
    • , Mychel R. P. T. Morais
    •  & Rachel Lennon
  • Reviews |

    Podocytopathies are kidney diseases in which podocyte injury drives proteinuria or nephrotic syndrome. This Primer discusses a shift in paradigm from patient stratification based on kidney biopsy findings towards personalized management based on clinical, morphological and genetic data.

    • Jeffrey B. Kopp
    • , Hans-Joachim Anders
    • , Katalin Susztak
    • , Manuel A. Podestà
    • , Giuseppe Remuzzi
    • , Friedhelm Hildebrandt
    •  & Paola Romagnani

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