Plasmacytoid dendritic cells articles within Nature Communications

Featured

• Article
  02 July 2021 | Open Access

  The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response

  Zinc finger proteins are involved in the resolution of immune responses and function by degrading mRNA of inflammatory cytokines. Here the authors show MCPIP3 promotes skin inflammation via modification of cytokine profiles in pDCs and macrophages.

  • Bo Liu
  • , Jiancheng Huang
  •  & Cliff Y. Yang

• Article
  01 December 2020 | Open Access

  Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity

  Type I interferon drives autoimmune pathology in SLE and has been assumed to come predominantly from plasmacytoid dendritic cells (pDCs). Here, the authors show that prior to the onset of SLE, pDCs lose multiple immunogenic functions and, instead, non-hematopoietic cells such as keratinocytes are a major source of type I interferons.

  • Antonios Psarras
  • , Adewonuola Alase
  •  & Edward M. Vital

• Article
  15 May 2020 | Open Access

  Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation

  Zika virus (ZIKV) poses a significant public health threat, but the immune landscape changes following ZIKV infection is still unclear. Here, the authors show, using flow cytometry and transcriptomic data, that ZIKV induces a multitude of immune responses, with plasmacytoid dendritic cells poised centrally to interact with other immune cell types.

  • Xiaoming Sun
  • , Stephane Hua
  •  & Xu G. Yu

• Article
  30 August 2018 | Open Access

  Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

  Plasmacytoid dendritic cells (pDC) are an important regulator of immune responses. Here the authors show that pDC precursors, similar to peripheral blood-derived pDCs, can be differentiated from human CD34⁺ hematopoietic stem and progenitor cells, with type I/II IFN priming being required for their functional maturation and differentiation.

  • A. Laustsen
  • , R. O. Bak
  •  & M. R. Jakobsen

• Article
  20 August 2018 | Open Access

  Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells

  Plasmacytoid dendritic cells (pDC) are a pivotal component of the immune system. Here, the authors utilize single-cell microfluidics to interrogate the human pDC compartment and reveal a subset of type I IFN secreting pDCs that is regulated by stochastic gene expression and amplified by microenvironmental cues.

  • Florian Wimmers
  • , Nikita Subedi
  •  & Jurjen Tel

• Article
  08 June 2018 | Open Access

  Mitochondrial reactive oxygen species regulate the induction of CD8⁺ T cells by plasmacytoid dendritic cells

  Cross-presentation allows exogenous antigens to be presented by the major histocompatibility I pathway. Here the authors show that the inducible cross-presentation by plasmacytoid dendritic cells is modulated by mitochondria-originated reactive oxygen species.

  • Marine Oberkampf
  • , Camille Guillerey
  •  & Gilles Dadaglio

• Article
  02 January 2018 | Open Access

  TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis

  The pathogenesis of paradoxical psoriasis in patients receiving anti-TNF treatments for classical psoriasis is unclear. Here, the authors show that anti-TNF drugs enhance the production of type I interferon by plasmacytoid dendritic cells, causing skin lesions that, unlike classical psoriasis, lack T- cell autoimmunity.

  • Curdin Conrad
  • , Jeremy Di Domizio
  •  & Michel Gilliet

• Article
  17 November 2017 | Open Access

  TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells

  Antiviral immune responses involve clustering of plasmacytoid dendritic cells (pDC) in response to endosomal TLR7-mediated sensing of viral RNA. Here the authors show the GTPase Arl8b controls translocation of TLR7⁺ endosomes to the periphery of the cell via microtubule interactions, thus enabling pDC clustering and type I interferon production.

  • Shin-Ichiroh Saitoh
  • , Fumiko Abe
  •  & Kensuke Miyake

• Article
  13 October 2017 | Open Access

  BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells

  TLR9 is highly expressed by plasmacytoid dendritic cells and detects nucleic acids, but to discriminate between host and microbial nucleic acids TLR9 is sorted into different endosomal compartments. Here the authors show that BAD-LAMP limits type 1 interferon responses by sorting TLR9 to late endosomal compartments.

  • Alexis Combes
  • , Voahirana Camosseto
  •  & Evelina Gatti

• Article
  31 May 2017 | Open Access

  HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells

  Low dose of the heat shock protein gp96 can drive effector T-cell responses, yet high-dose gp96 is immunosuppressive by expanding the regulatory T-cell population. Here the authors explain this dichotomy by showing that high-dose gp96 can drive plasmacytoid dendritic cell expression of neuropilin-1, thus functionally supporting interaction with Treg cells.

  • Lauren B. Kinner-Bibeau
  • , Abigail L. Sedlacek
  •  & Robert J. Binder

• Article
  09 February 2017 | Open Access

  Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

  Plasmacytoid dendritic cells produce type I interferons in response to viral sensing. Here the authors show that amines inhibit these plasmacytoid dendritic cell responses through CXCR4 engagement.

  • Nikaïa Smith
  • , Nicolas Pietrancosta
  •  & Jean-Philippe Herbeuval

• Article | 18 July 2014

  A micro-sterile inflammation array as an adjuvant for influenza vaccines

  There is a need of improved adjuvants for influenza vaccines. Here, the authors describe an adjuvant strategy using micro-fractional laser treatment combined with a topical cream containing a TLR 7 ligand that can enhance the immune response to intradermal vaccination with transient, constrained local inflammation.

  • Ji Wang
  • , Dilip Shah
  •  & Mei X. Wu