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Review Article |
RNA-directed DNA methylation: an epigenetic pathway of increasing complexity
RNA-directed DNA methylation (RdDM) is a major mechanism of transcriptional gene silencing in plants that is mediated through small interfering RNAs (siRNAs) and plant-specific RNA polymerases. This Review summarizes our latest understanding of RdDM, including its genomic targets, molecular mechanisms (such as emerging non-canonical pathways) and diverse biological roles.
- Marjori A. Matzke
- & Rebecca A. Mosher