Pituitary gland

Stem cells in the pituitary master gland remain mystifying; moreover, they have hardly been explored in humans. A new study applied transcriptome and chromatin accessibility profiling at single-cell resolution to human postmortem pituitary glands from individuals of different ages, thereby providing insights into the heterogeneity and regulatory mechanisms of the projected human pituitary stem cell population.

The first large-scale, multicentric analysis of long-term results with Gamma Knife (Elekta) radiosurgery in the therapeutically challenging area of Cushing disease shows that, in selected patients, this radiation technique enables hormonal control to be achieved in most patients with relatively few adverse effects but with a significant risk of disease recurrence.