Technology Feature |
Featured
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Method to Watch |
Synthetic tissue environments
Artificial ECMs enable recapitulation of tissue microenvironments.
- Madhura Mukhopadhyay
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This Month |
Happy labiversary
They started their lab mid-COVID. The new principal investigator adventure is a roller-coaster ride with some unexpected surprises.
- Vivien Marx
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This Month |
How to stay social
Many scientists are active on social media, especially Twitter. The social media world is changing, but these researchers want to stay socially connected.
- Vivien Marx
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This Month |
Hi, new PI
Your name is on the door to your new lab. Life is getting exciting and turbulent.
- Vivien Marx
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This Month |
Lab retreats for stepping away and moving closer
A blend of science, food and fun can empower well-being and new connections.
- Vivien Marx
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This Month |
Everyday ups and downs for LGBT+ scientists
How to gauge academic culture and celebrate being an LGBT+ scientist.
- Vivien Marx
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Technology Feature |
Modeling the early embryo
Widespread adoption of new embryo models hinges on how faithfully they mirror real embryos.
- Vivien Marx
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Research Highlight |
Synthetic tumor microenvironments
An artificial system models the mechanical properties of the tumor microenvironment in vitro.
- Madhura Mukhopadhyay
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Research Highlight |
Trapping virus in a shell
Researchers design DNA shells to trap virus particles and thus prevent interactions between viruses and host cells.
- Lei Tang
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Research Highlight |
Walking through chromatin modifications
The Cell-TALKING technique probes DNA modifications around a histone modification in fixed cells.
- Lei Tang
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Research Highlight |
Ordering protein arrays on cells
Researchers report a method to generate two-component protein arrays on living cells, which enables controlled receptor clustering.
- Lei Tang
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Editorial |
In celebration of chemistry
The year 2019 marks two noteworthy anniversaries in chemistry. We use this opportunity to reflect on the importance of chemistry to Nature Methods and to the broader life science research community.
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Research Highlight |
Corrected in vivo imaging
Aberration correction adds depth to light-sheet microscopy.
- Zachary J. Lapin
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Research Highlights |
Live-streaming the cytoplasm
A new approach uses beams of light to direct cytoplasmic flows.
- Tal Nawy
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Research Highlights |
Sequencing DNA, no mistake
Building redundancy into fluorogenic sequencing makes for error-free DNA sequence reads.
- Tal Nawy
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Technology Feature |
Structural biology: doors open at the European XFEL
X-ray beams at 27,000 pulses per second promise high-resolution views of macromolecules.
- Vivien Marx
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Research Highlights |
GPCR interactions in space and time
A proximity labeling technique yields new insights into GPCR signaling.
- Allison Doerr
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Methods in Brief |
Probing protein mechanics with an electric field
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News & Views |
Cool and dynamic: single-molecule fluorescence-based structural biology
New methods exploit single-molecule measurements to study protein structure and dynamics.
- Timothy D Craggs
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Methods in Brief |
Printing human-scale tissues in three dimensions
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Research Highlights |
Lock-and-key PORE-igami
A nanopore built from DNA allows the controlled and selective transport of organic molecules across a lipid membrane.
- Stéphane Larochelle
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Methods in Brief |
Adapting to aberrations in brain imaging
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Research Highlights |
Tracking expression through the generations
A microfluidic device tracks the lineage and transcriptional profiles of individual cells.
- Tal Nawy
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Tools in Brief |
A guide to cellular transdifferentiation
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Advertising Feature: Application Note |
HyVolution—the smart path to confocal super-resolution
- Rolf Theodor Borlinghaus
- & Constantin Kappel
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This Month |
Multiple linear regression
When multiple variables are associated with a response, the interpretation of a prediction equation is seldom simple.
- Martin Krzywinski
- & Naomi Altman
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Tools in Brief |
Sustainable magnetic nanoparticle synthesis
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Tools in Brief |
Synapses under the spotlight
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Tools in Brief |
An improved single-molecule fluorophore
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Editorial |
Matters of significance
Sound experimental design and analysis require improved statistical training.
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Methods in Brief |
Rapid reaction inspection
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This Month |
Storytelling
Relate your data to the world around them using the age-old custom of telling a story.
- Martin Krzywinski
- & Alberto Cairo
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Methods in Brief |
Reaction discovery by mass spectrometry
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Methods in Brief |
Building DNA gridirons
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This Month |
Elements of visual style
Translate the principles of effective writing to the process of figure design.
- Martin Krzywinski
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This Month |
Axes, ticks and grids
Make navigational elements distinct and unobtrusive to maintain visual priority of data.
- Martin Krzywinski
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Methods in Brief |
DNA nanostructures built from bricks
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Correspondence |
Accelerating 3B single-molecule super-resolution microscopy with cloud computing
- Ying S Hu
- , Xiaolin Nan
- & Hu Cang
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Technology Feature |
Where stem cells call home
By building engineered microenvironments, scientists probe the many talents of stem cells.
- Vivien Marx
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Method to Watch |
Defective (but useful) diamonds
Nitrogen vacancy center defects in diamonds confer remarkably useful properties.
- Daniel Evanko
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Research Highlights |
Dye shines bright
A tiny lightning rod made of two gold particles and a DNA pillar creates a hotspot that brightens fluorescent signals in zeptoliter volumes.
- Vivien Marx
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Correspondence |
Fluorescence and super-resolution standards based on DNA origami
- Jürgen J Schmied
- , Andreas Gietl
- & Philip Tinnefeld
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This Month |
Visualizing biological data
Data visualization is increasingly important, but it requires clear objectives and improved implementation.
- Bang Wong
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This Month |
Pencil and paper
A unique set of tools facilitate thinking and hypothesis generation.
- Bang Wong
- & Rikke Schmidt Kjærgaard
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Tools in Brief |
Towards single-molecule mass spectrometry
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This Month |
Power of the plane
Two-dimensional visualizations of multivariate data are most effective when combined.
- Nils Gehlenborg
- & Bang Wong
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Research Highlights |
A sensor that makes sense
A 'neutralizer displacement assay' provides a general platform for electrochemistry-based sensing of any class of analyte molecule.
- Allison Doerr
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This Month |
Into the third dimension
Three-dimensional visualizations are effective for spatial data but rarely for other data types.
- Nils Gehlenborg
- & Bang Wong
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This Month |
Mapping quantitative data to color
Data structure informs choice of color maps.
- Nils Gehlenborg
- & Bang Wong